528882-16-8

Basic information

• Product Name: 3-(N-TERT-BUTOXYCARBONYL-N-METHYLAMINO)ANILINE
• Synonyms: 3-(N-TERT-BUTOXYCARBONYL-N-METHYLAMINO)ANILINE;3-N-Boc-N-methyl amino aniline;(3-Aminophenyl)methylcarbamic acid tert-butyl ester;tert-butyl 3-aMinophenyl(Methyl)carbaMate;3-(N-TERT-BUTOXYCARBONYL-N-METHYLAMINO)ANILINE (Related Reference)
• CAS NO: 528882-16-8
• Molecular Formula: C₁₂H₁₈N₂O₂
• Molecular Weight: 222.28352
• Mol File: 528882-16-8.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 347.824 °C at 760 mmHg
• Flash Point: 164.158 °C
• Appearance: /
• Density: 1.116 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 3-(N-TERT-BUTOXYCARBONYL-N-METHYLAMINO)ANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(N-TERT-BUTOXYCARBONYL-N-METHYLAMINO)ANILINE(528882-16-8)
• EPA Substance Registry System: 3-(N-TERT-BUTOXYCARBONYL-N-METHYLAMINO)ANILINE(528882-16-8)

Safety Data

• Hazardous Substances Data: 528882-16-8(Hazardous Substances Data)

Usage

General Description

3-(N-Tert-butoxycarbonyl-N-methylamino)aniline is a chemical compound with a molecular formula of C13H20N2O2. It is used as a reagent in organic synthesis for the modification of amino acids and peptides. The tert-butoxycarbonyl (Boc) group protects the amino group from unwanted reactions, allowing for selective manipulation of other functional groups. 3-(N-Tert-butoxycarbonyl-N-methylamino)aniline is commonly used in peptide synthesis and pharmaceutical research as a building block for the production of various drugs and bioactive molecules. It is important to handle this compound with caution and follow proper safety protocols due to its potential hazards.

Upstream product

• 99-09-2 3-nitro-aniline 
• 24424-99-5 di-tert-butyl dicarbonate 
• 18437-64-4 tert-butyl (3-nitrophenyl)carbamate 
• 3320-87-4 isocyanic acid (3-nitro-phenyl) ester 
• 528882-15-7 N-methyl-(3-nitrophenyl)carbamic acid tert-butyl ester 

Downstream Products

• 1188276-91-6 {4-[3-(2,6-Dichloro-phenyl)-1-methyl-2-oxo-1,2-dihydro-[1,6]naphthyridin-7-ylamino] benzyl}-carbamic acid tert-butyl ester 
• 1228466-13-4 tert-butyl methyl{3-[(trifluoroacetyl)amino]phenyl}carbamate 
• 1228465-61-9 N-{5-[(3-{[(4-tert-butylphenyl)carbamoyl]amino}phenyl)(methyl)amino][1,3]thiazolo[5,4-b]pyridin-2-yl}cyclopropanecarboxamide 
• 1228466-14-5 2,2,2-trifluoro-N-[3-(methylamino)phenyl]acetamide 
• 1228466-15-6 2,2,2-trifluoro-N-{3-[methyl(5-nitropyridin-2-yl)amino]phenyl}acetamide 
• 1228466-17-8 N-{3-[(2-amino[1,3]thiazolo[5,4-b]pyridin-5-yl)(methyl)amino]phenyl}-2,2,2-trifluoroacetamide 
• 1228531-94-9 N-[3-[(5-aminopyridin-2-yl)(methyl)amino]phenyl]-2,2,2-trifluoroacetamide 
• 1228466-18-9 N-[5-(methyl{3-[(trifluoroacetyl)amino]phenyl}amino)[1,3]thiazolo[5,4-b]pyridin-2-yl]cyclopropanecarboxamide 
• 1228466-19-0 N-{5-[(3-aminophenyl)(methyl)amino][1,3]thiazolo[5,4-b]pyridin-2-yl}cyclopropanecarboxamide 
• 1228465-62-0 N-(5-{methyl[3-({[4-(trifluoromethoxy)phenyl]carbamoyl}amino)phenyl]amino}[1,3]thiazolo[5,4-b]pyridin-2-yl)cyclopropanecarboxamide 
• 1228465-64-2 N-(5-{[3-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenyl](methyl)amino}[1,3]thiazolo[5,4-b]pyridin-2-yl)cyclopropanecarboxamide 
• 1228465-63-1 N-(5-{methyl[3-({[4-(trifluoromethyl)phenyl]carbamoyl}amino)phenyl]amino}[1,3]thiazolo[5,4-b]pyridin-2-yl)cyclopropanecarboxamide 
• 1616380-97-2 tert-butyl (3-((2-chloro-5-fluoropyrimidin-4-yl)amino)phenyl)(methyl)carbamate 
• 1202759-89-4 tert-butyl (3-((2-chloro-5-fluoropyrimidin-4-yl)amino)phenyl)carbamate 

Relevant articles and documents

FUSED PYRIMIDINE COMPOUNDS, COMPOSITIONS AND MEDICINAL APPLICATIONS THEREOF

The present disclosure relates to a class of fused pyrimidine compounds of Formula I, their stereoisomers, tautomers, pharmaceutically acceptable salts, polymorphs, solvates, and hydrates thereof. The present disclosure also relates to a process of preparation of these fused pyrimidine compounds, and to pharmaceutical compositions containing them.

COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 4 POLYPEPTIDES

The present disclosure relates to bifunctional compounds, which find utility as modulators of Interleukin-1 Receptor-Associated Kinase 4 (IRAK-4); the target protein). In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a Von Hppel-Lindau, cereblon, ligand which binds to the E3 ubiquitin ligase and on the other end a moiety which binds the target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation or accumulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.

HETEROARYL COMPOUNDS AND USES THEREOF

The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.