528885-73-6

Upstream product

• 17640-15-2 methyl cyanoformate 
• 40649-34-1 6-allyl-3-isobutoxycyclohex-2-en-1-one 

Downstream Products

• 436146-29-1 4-allyl-4-benzyloxymethyl-cyclohex-2-enone 
• 436146-30-4 4-allyl-4-methoxymethoxymethyl-6-methyl-cyclohex-2-enone 
• 436145-97-0 (+/-)-4-methoxymethoxymethyl-4-(2-propenyl)cyclohex-2-en-1-one 
• 436145-96-9 (+/-)-4-oxo-1-(2-propenyl)-2-cyclohexene-1-methanol 

Relevant academic research and scientific papers

Diastereoselective formal total synthesis of the DNA polymerase alpha inhibitor, aphidicolin, using palladium-catalyzed cycloalkenylation and intramolecular Diels-Alder reactions.

[structure: see text] A novel diastereoselective formal synthesis of aphidicolin has been achieved by exploiting a unique characteristic of a bicyclo[3.2.1]octane prepared by employing a palladium-catalyzed cycloalkenylation process.

Some aspects of palladium-catalyzed cycloalkenylation: Developments of environmentally benign catalytic conditions and demonstration of tandem cycloalkenylation

The influences of catalysts, substituent groups, and solvents on the palladium-catalyzed cycloalkenylation of cross-conjugated silyl enol ethers of 2-tert-butyldimethylsiloxy-5-(2-propenyl)-1,3-cyclohexadiene derivatives have been investigated. The catalytic reaction proceeded smoothly, even in aqueous media. The product ratios were influenced by the structure of substrates as well as solvents. In addition, it was found that the reaction is applicable to a tandem cyclization for the construction of cedrane skeleton.