52890-05-8Relevant academic research and scientific papers
Intramolecular Cooperative Reactions of 1,2-Bis(diazoketone)s. The First Syntheses of trans-Hydro-1H-2-inden-1-ones
Nakatani, Kazuhiko,Takada, Kazunori,Isoe, Sachihiko
, p. 2466 - 2473 (2007/10/02)
The intramolecular cooperative reactions of 1,2-bis(diazoketone)s initiated by the Wolff rearrangement of α-diazoketones have been investigated.Under thermal conditions, 1,2-bis(diazoketone)s are efficiently transformed into 2-cyclopenten-1-one derivatives with complete stereospecificity.Thus, a most extraordinary result is reported, that trans-hydro-2-inden-1-ones (1-3) were synthesized for the first time from trans-1,2-bis(diazoketone)s (5, 11, and 12), respectively.The unprecedented trans-hydroindenone structure was confirmed by X-ray analysis of 3 as well as 1H NMR analysis and was supported by ab initio molecular orbital calculations.The same reactions were also carried out under photochemical conditions and were applied to 1,3-bis(diazoketone)s, giving 2-cyclohexen-1-one derivatives.
Stereocontrolled Syntheses for the Six Diastereomeric 1,2-Dihydroxy-4,5-diaminocyclohexanes: PtII Complexes and P-388 Antitumor Properties
Witiak, Donald T.,Rotella, David P.,Filppi, Joyce A.,Gallucci, Judith
, p. 1327 - 1336 (2007/10/02)
Stereocontrolled syntheses for the six diastereomeric 1,2-dihydroxy-4,5-diaminocyclohexanes 3a-f from cyclohexene diamines cis-4 and trans-5 are described.Cbz-protected species cis-9 and trans-11, respectively, served as a source of stable Cbz-protected p
