52898-20-1

Basic information

• Product Name: 6-(3-methyl-2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoic acid
• Synonyms: 1H-Pyrrole-1-hexanoic acid, 2,5-dihydro-3-methyl-2,5-dioxo-
• CAS NO: 52898-20-1
• Molecular Formula: C₁₁H₁₅NO₄
• Molecular Weight: 225.2411
• Mol File: 52898-20-1.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 411°C at 760 mmHg
• Flash Point: 202.3°C
• Density: 1.235g/cm³
• Vapor Pressure: 6.63E-08mmHg at 25°C
• Refractive Index: 1.526
• CAS DataBase Reference: 6-(3-methyl-2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(3-methyl-2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoic acid(52898-20-1)
• EPA Substance Registry System: 6-(3-methyl-2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoic acid(52898-20-1)

Safety Data

• Hazardous Substances Data: 52898-20-1(Hazardous Substances Data)

Upstream product

• 616-02-4 citraconic acid anhydride 
• 60-32-2 6-aminohexanoic acid 

Relevant articles and documents

Cancer-targeting antibody-drug conjugates: Site-specific conjugation of doxorubicin to anti-EGFR 528 Fab′ through a polyethylene glycol linker

Antibodydrug conjugates have been prepared to examine the effect that attaching small-molecule drugs to an antibody fragment has on antibody activity. The anticancer drug doxorubicin was covalently attached through a polyethylene glycol linker to a cancer-targeting, anti-epidermal growth factor receptor antibody fragment (Fab′). The reactivity of maleimide was compared with a substituted maleimide derivative (citraconimide) in conjugation reactions with cysteine residues on a Fab′. Introduction of polyethylene glycol increased aqueous solubility of the cytotoxic drug, which led to an improvement in overall yield of the conjugation reaction with the antibody fragment. Antibodydrug conjugates prepared retained activity of the parent antibody, as determined by antigen binding experiments measured by surface plasmon resonance.