52898-53-0Relevant academic research and scientific papers
Imino 1,2-Wittig rearrangement of hydroximates and its application to synthesis of cytoxazone
Miyata, Okiko,Koizumi, Tomoko,Asai, Hiroshi,Iba, Ryuichi,Naito, Takeaki
, p. 3893 - 3914 (2007/10/03)
The imino 1,2-Wittig rearrangement of hydroximates provides a novel method for the construction of 2-hydroxyoxime ethers. Upon treatment with LDA, Z-hydroximates smoothly underwent stereoselective rearrangement to give Z-2-hydroxyoxime ethers in good yield, which were converted into amino alcohols. On the other hand, the rearrangement of E-hydroximates gave a mixture of E- and Z-2-hydroxyoxime ethers. This method was successfully applied to a practical synthesis of cytoxazone.
Formation of Ketone Diperoxides from Ozonation of O-Methyloximes
Ito, Yoshikatsu,Yokoya, Hiroaki,Umehara, Yasutoshi,Matsuura, Teruo
, p. 2407 - 2408 (2007/10/02)
The ozonation of the O-methyloximes has been investigated.Besides the corresponding ketones, ketone diperoxides, and N-methoxyamides were produced.The stereochemistry of the ketone diperoxides was studied by the NMR technique.
