52899-07-7

Basic information

• Product Name: H-PRO-LEU-OH
• Synonyms: L-PROLYL-L-LEUCINE;H-PRO-LEU-OH;PRO-LEU;(R)-4-Methyl-2-((R)-pyrrolidine-2-carboxaMido)pentanoic acid;H2N-Pro-Leu-OH
• CAS NO: 52899-07-7
• Molecular Formula: C₁₁H₂₀N₂O₃
• Molecular Weight: 228.29
• Product Categories: Dipeptides;Dipeptides and Tripeptides;Peptides
• Mol File: 52899-07-7.mol
• Article Data: 1

Chemical Properties

• Melting Point: 253-255℃
• Boiling Point: 457.5°C at 760 mmHg
• Flash Point: 230.5°C
• Appearance: /
• Density: 1.126g/cm³
• Vapor Pressure: 1.21E-09mmHg at 25°C
• Refractive Index: 1.496
• Storage Temp.: -15°C
• PKA: 3.55±0.21(Predicted)
• CAS DataBase Reference: H-PRO-LEU-OH(CAS DataBase Reference)
• NIST Chemistry Reference: H-PRO-LEU-OH(52899-07-7)
• EPA Substance Registry System: H-PRO-LEU-OH(52899-07-7)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 52899-07-7(Hazardous Substances Data)

Usage

General Description

H-PRO-LEU-OH is a chemical compound consisting of the amino acids proline and leucine linked together. Amino acids are the building blocks of proteins and play crucial roles in various biological processes. Proline is a non-essential amino acid that is involved in collagen formation and the maintenance of skin and connective tissues, while leucine is an essential amino acid that plays a key role in protein synthesis, muscle growth, and the regulation of blood sugar levels. H-PRO-LEU-OH may be used in research and biotechnological applications related to studying protein structures and functions, as well as in the development of pharmaceuticals and therapeutics targeting specific biological pathways.

InChI:InChI=1/C11H20N2O3/c1-7(2)6-9(11(15)16)13-10(14)8-4-3-5-12-8/h7-9,12H,3-6H2,1-2H3,(H,13,14)(H,15,16)

Downstream Products

• 274680-11-4 3-(2-methylpropyl)hexahydropyrrolo[1,2-a]pyrazin-1,4-dione 
• 36238-67-2 (3R,8aS)-hexahydro-3-(2-methylpropyl)pyrrolo[1,2-a]pyrazine-1,4-dione 
• 2873-36-1 (3S,8aR)-3-isobutyl-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione 
• 2873-36-1 cyclo(L-Pro-L-Leu) 
• 1154050-07-3 (p-iodobenzoyl-L-prolyl)-L-leucine 
• 61-90-5 L-leucine 
• 147-85-3 L-proline 

Relevant articles and documents

Model studies of competing hydrolysis and epimerization of some tetrapeptides of interest in amino acid racemization studies in geochronology

The processes of epimerization of individual peptide units in proteins and the concurrent cleavage of peptide bonds are modelled by heating some tetrapeptide and tetrapeptide derivatives to 148.5 deg C in pH 6.8 phosphate buffer.An excess of D-proline was observed during the heating of L-propyl-L-leucylglycylglycine.The D/L ratio of proline attains a maximum value of 2.1 after 90 minutes.The excess D-proline is attributed to the formation of a 2.3:1 mixture of diketopiperazines cyclo-(D-propyl-L-leucyl) and cyclo-(L-prolyl-L-leucyl).These two species account for most of the leucine and proline in the final mixture after the tetrapeptide is no longer detectable.Only small amounts of prolylleucine can be detcected after 50 hours.It is suggested that the above tetrapeptide undergoes internal aminolysis.Leucine in the tetrapeptide glycyl-L-leucylglycylglycine racemizes three times faster than in L-propyl-L-leucylglycylglycine.This demonstrates that an amino acid residue in a peptide chain does have an effect upon the rate of epimerization of a neighbouring peptide residue.A discussion of the geochemical implications of the results is included.