52912-57-9

Upstream product

• 762-04-9 phosphonic acid diethyl ester 
• 106-40-1 4-bromo-aniline 
• 762-04-9 Diethyl phosphonate 
• 814-49-3 diethyl chlorophosphate 

Downstream Products

• 38874-30-5 (4-bromo-phenyl)-amidophosphoric acid 
• 1266570-41-5 2-(4-bromophenyl)-1,3,4,9,9-pentaphenyl-4,9-dihydro-2H-benzo[f]isoindol-4-ol 
• 1266570-22-2 diethyl 4-bromophenyl(1,3,3-triphenylpropa-1,2-dienyl)phosphoramidate 

Relevant academic research and scientific papers

Electrochemical phosphorylation of arenols and anilines leading to organophosphates and phosphoramidates

A practical phosphorylation for generating organophosphates and phosphoramidatesviaelectrochemical dehydrogenative cross-coupling of P(O)H compounds with arenols and anilines is disclosed. This method involves using inorganic iodide salts as both redox catalysts and electrolytes in an undivided cell without the addition of oxidants or bases. A preliminary mechanistic study suggests that radicals are not involved in this process. This method is green and eco-friendly and has good functional group tolerance, high yields and broad substrate scope, with the potential for practical synthesis.

Organophotocatalytic Synthesis of Phosphoramidates

We describe the use of visible light in conjunction with an organic dye for the synthesis of phosphoramidates. Cross dehydrogenative coupling reactions between phosphites and amines are reported using organic dyes and light as catalysts for the first time. It is not only a novel application of organic dyes but also fulfils the requirement of sustainability and green chemistry avoiding the use of chromatographic purification techniques. The product was simply isolated from the reaction mixture via an acid-base work-up procedure, rendering the pure product in good yields.

Fe3O4@MgO nanoparticles as an efficient recyclable catalyst for the synthesis of phosphoroamidates via the Atherton-Todd reaction Dedicated to Professor Tsutomu Yokomatsu from Tokyo University of Pharmacy and Life Sciences on the occasion of his 65th birthday

A simple and efficient method is presented for the synthesis of phosphoroamidates in moderate to good yield via the Atherton-Todd coupling of primary amines with H-dialkyl phosphites using Fe3O4@MgO nanoparticles as a recyclable catalyst.

Microwave-assisted cleavage of phosphate, phosphonate and phosphoramide esters

A mild and rapid protocol for cleavage of phosphate, phosphonate and phosphoramide esters. The scope and limitations of this microwave-assisted reaction is explored here.