52916-86-6

Upstream product

• 1866-39-3 trans-p-methylcinnamic acid 
• 1866-39-3 4-methylcinnamic acid 
• 104-87-0 4-methyl-benzaldehyde 

Downstream Products

• 60655-80-3 2-bromo-1-(4-methylphenyl)ethylene 
• 2227-58-9 3-(4-methylphenyl)prop-2-ynoic acid 
• 73839-44-8 (Z)-1-[2-bromovinyl]-4-methylbenzene 
• 60655-80-3 (E)-4-methylstyrenyl bromide 
• 5301-96-2 4-(p-tolyl)-1H-[1,2,3]triazole 
• 766-97-2 4-n-methylphenylacetylene 
• 62849-00-7 p-Tolyl-propynoyl chloride 
• 1607020-74-5 N-(4-methylphenyl)-3-exo-4-methylbenzylidenetricyclo[3.2.1.02,4]octane-6,7-endo-dicarboximide 
• 1607020-86-9 3-exo-(4-methylbenzylidene)tricyclo[3.2.1.02,4]octane 
• 1607020-82-5 N-isobutyl-3-exo-(4-methylbenzylidene)tricyclo[3.2.1.02,4]octane-6,7-endo-dicarboximide 
• 87212-87-1 (1Z,3Z)-1,4-di-p-tolylbuta-1,3-diene 
• 14290-88-1 (2Z)-3-(4-methylphenyl)propenoic acid 
• 93501-03-2 2,3-Dibromo-3-p-tolyl-thiopropionic acid S-p-tolyl ester 
• 93500-99-3 2,3-Dibromo-3-p-tolyl-propionic acid p-tolyl ester 

Relevant academic research and scientific papers

Palladium-Catalyzed Two-Component Domino Coupling Reaction of (Z)-β-Bromostyrenes with Norbornenes: Synthesis of 1,5-Enynes

Polyfunctional molecules, 1,5-enynes, have been achieved via a palladium(0)-catalyzed domino coupling reaction of (Z)-β-bromostyrenes with norbornenes in the presence of cesium carbonate and N,N-dimethylformamide. The process involves a double Heck-type procedure, two-fold C(sp2) H activation and formation of two carbon-carbon bonds. There are possibilities of diversified transformation for the domino coupling of (Z)-β-bromostyrenes with norbornenes, the procedure is successfully driven to 1,5-enynes via accurate adjustment of the reaction conditions. (Figure presented.) .

Method for synthesizing alpha,beta-dibromide

The invention discloses a method for synthesizing alpha,beta-dibromide. The method is characterized in that a styrene compound as shown in the formula I is taken as a raw material, Zn-Al hydrotalciteZnAl-BrO3-LDHs of a bromate intercalation is taken as

A Facile Access to trans -3-Styryl-4-hydrazinocyclopentenes via Palladium-Catalyzed Ring Opening of Diazanorbornenes with (Z)-β-Bromostyrenes/2,3-Dibromohydrocinnamic Acids

trans -3-Styryl-4-hydrazinocyclopentenes have been synthesized via palladium-catalyzed desymmetrization of diazanorbornenes with (Z)-β-bromostyrenes. The reaction also works well with (Z)-β-bromostyrenes generated in situ from 2,3-dibromohydrocinnamic acids. The synthesized hydrazinocyclopentenes provide an easy route towards synthetic intermediates of many scaffolds of biological potential.

Carbene-catalyzed LUMO activation of alkyne esters for access to functional pyridines

A carbene-catalyzed LUMO activation of α,β-unsaturated alkyne esters is reported. This catalytic process allows for effective reactions of alkyne esters with enamides to synthesize functional pyridines via simple protocols. A previously unexplored unsaturated alkyne acyl azolium intermediate is involved in the key step of the reaction.

Palladium(0)-Catalyzed Methylcyclopropanation of Norbornenes with Vinyl Bromides and Mechanism Study

An unusual methylcyclopropanation from [2 + 1] cycloadditions of vinyl bromides to norbornenes catalyzed by Pd(OAc)2/PPh3 in the presence of CH3ONa and CH3OH has been established. A methylcyclopropane subunit was installed by a 3-fold domino procedure involving a key protonation course. Preliminary deuterium-labeling studies revealed that the proton came from methyl of CH3OH and also exposed an additional hydrogen/deuterium exchange process. These two proton-concerned reactions were fully chemoselective.

Palladium(0)-catalyzed methylenecyclopropanation of norbornenes with vinyl bromides

Highly strained methylenecyclopropane derivatives have been achieved via a novel and efficient Pd(0)-catalyzed domino reaction. The formal [2 + 1] cycloaddition reaction of vinyl bromides to norbornenes involves a Heck-type coupling and a C(sp2)-H bond activation.

Palladium-catalyzed [2+1+1] annulation of norbornenes with (z)-bromostyrenes: Synthesis of bismethylenecyclobutanes via twofold C(sp2)-H bond activation

The first Pd-catalyzed intermolecular [2+1+1] annulation reaction of (Z)-bromostyrene derivatives and norbornenes has been realized. Bismethylenecyclobutane derivatives were obtained with high yields. The domino coupling reaction involves a double Heck-type coupling process, twofold C(sp2)-H bond activation and formation of three carbon-carbon bonds.

Convenient synthesis of terminal alkynes from anti-3-aryl-2,3- dibromopropanoic acids using a K2CO3/DMSO system

A convenient, efficient, and generally applicable method was developed for the synthesis of terminal alkynes from anti-3-aryl-2,3-dibromopropanoic acids in the presence of DMSO and K2CO3.

Synthesis of (Z)-1-bromo-1-alkenes and terminal alkynes from anti-2,3-dibromoalkanoic acids by microwave-induced reaction

(Z)-1-Bromo-1-alkenes were stereoselectively prepared in high yields in a short reaction time by microwave irradiation of the corresponding anti-2,3-dibromoalkanoic acids in a Et3N/DMF system. A one-pot synthesis of terminal alkynes and enynes from 2,3-dibromoalkanoic acids were also developed by microwave-induced reaction.

Convenient and stereoselective synthesis of (Z)-1-bromo-1-alkenes by microwave-induced reaction

(Z)-1-Bromo-1-alkenes were stereoselectively prepared in high yields in a short reaction time (0.2-1.0 min) by microwave irradiation of the corresponding 2,3-dibromoalkanoic acids in DMF in the presence of triethylamine.