5292-48-8

Usage

Common Uses

Synthesis of pharmaceuticals
Synthesis of agrochemicals
Synthesis of dyes
Plasticizer in the production of polyvinyl chloride (PVC) and other polymers

Toxicity

Toxic to aquatic organisms

Environmental Impact

May cause long-term adverse effects in the aquatic environment

Handling and Disposal

Should be handled and disposed of with care to prevent harm to human health and the environment

Chemical Structure

Ester derivative of 1,4-Benzenedicarboxylic acid with a fluorine atom at the 2nd position and a nitro group at the 5th position, and two methyl groups attached to the carboxylic acid groups

Physical State

Likely a solid at room temperature, though exact physical properties are not provided

Molecular Weight

Not provided, but can be calculated from the molecular formula

Appearance

Not provided, but may be a yellow or colorless solid based on similar compounds

Solubility

Not provided, but likely soluble in organic solvents like ethanol or acetone

Stability

Not provided, but may be sensitive to heat, light, or moisture based on the presence of a nitro group

Reactivity

Not provided, but the nitro group may be reactive with reducing agents or bases

Regulatory Status

Not provided, but may be subject to environmental or workplace safety regulations due to its toxicity and potential environmental impact.

Upstream product

• 5292-47-7 1,4-dimethyl 2-fluorobenzene-1,4-dicarboxylate 
• 312591-22-3 dimethyl 2-bromo-5-nitroterephthalate 

Downstream Products

• 5292-49-9 2-amino-5-fluoro-terephthalic acid dimethyl ester 
• 864293-48-1 dimethyl 2-amino-5-methxoyterephthalate 
• 864293-47-0 dimethyl-2-methoxy-5-nitroterephthalate 
• 566158-06-3 2-fluoro-5-phenylamino-terephthalic acid dimethyl ester 
• 566158-69-8 2-fluoro-N-(2-(3-(methylthio)phenyl)propan-2-yl)-9-oxo-9,10-dihydroacridine-3-carboxamide 
• 566160-51-8 C₂₄H₂₁FN₂O₂S 
• 566158-07-4 2-fluoro-5-phenylamino-terephthalic acid 

Relevant academic research and scientific papers

PROLYL HYDROXYLASE INHIBITORS

The invention described herein relates to certain 2,4-dioxo-l,2,3,4-tetrahydro-7- quinazolinecarboxamide derivatives of formula (I) which are antagonists of HIF prolyl hydroxylases and are useful for treating diseases benefiting from the inhibition of this enzyme, anemia being one example.

Acridone-based inhibitors of inosine 5′-monophosphate dehydrogenase: Discovery and SAR leading to the identification of N-(2-(6-(4-ethylpiperazin-1- yl)pyridin-3-yl)propan-2-yl)-2-fluoro-9-oxo-9,10-dihydroacridine-3-carboxamide (BMS-566419)

Inosine monophosphate dehydrogenase (IMPDH), a key enzyme in the de novo synthesis of guanosine nucleotides, catalyzes the irreversible nicotinamide-adenine dinucleotide dependent oxidation of inosine-5′- monophosphate to xanthosine-5′-monophosphate. Mycophenolate Mofetil (MMF), a prodrug of mycophenolic acid, has clinical utility for the treatment of transplant rejection based on its inhibition of IMPDH. The overall clinical benefit of MMF is limited by what is generally believed to be compound-based, dose-limiting gastrointestinal (GI) toxicity that is related to its specific pharmacokinetic characteristics. Thus, development of an IMPDH inhibitor with a novel structure and a different pharmacokinetic profile may reduce the likelihood of GI toxicity and allow for increased efficacy. This article will detail the discovery and SAR leading to a novel and potent acridone-based IMPDH inhibitor 4m and its efficacy and GI tolerability when administered orally in a rat adjuvant arthritis model.