52939-06-7 Usage
Uses
Used in Pharmaceutical Research:
5-(4-AMINOPHENYL)FURAN-2-CARBOXYLIC ACID METHYL ESTER is used as a research compound for its potential role in the development of new pharmaceuticals. Its unique structure allows it to be a key component in the synthesis of bioactive molecules, contributing to the advancement of drug discovery.
Used in Drug Synthesis:
In the pharmaceutical industry, 5-(4-AMINOPHENYL)FURAN-2-CARBOXYLIC ACID METHYL ESTER is used as a building block in the synthesis of various drugs. Its versatile chemical properties enable it to be incorporated into a wide range of molecular structures, facilitating the creation of novel therapeutic agents.
Used in Disease Treatment Research:
5-(4-AMINOPHENYL)FURAN-2-CARBOXYLIC ACID METHYL ESTER is studied for its potential use in the treatment of certain diseases and conditions. Its specific chemical features may offer therapeutic benefits, making it a promising candidate for further research and development in medical applications.
Used in Bioactive Molecule Synthesis:
5-(4-AMINOPHENYL)FURAN-2-CARBOXYLIC ACID METHYL ESTER is also used as a precursor in the synthesis of bioactive molecules. Its presence in these molecules can enhance their biological activity, making it a valuable component in the development of new pharmaceutical agents with specific therapeutic effects.
Check Digit Verification of cas no
The CAS Registry Mumber 52939-06-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,2,9,3 and 9 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 52939-06:
(7*5)+(6*2)+(5*9)+(4*3)+(3*9)+(2*0)+(1*6)=137
137 % 10 = 7
So 52939-06-7 is a valid CAS Registry Number.
InChI:InChI=1/C12H11NO3/c1-15-12(14)11-7-6-10(16-11)8-2-4-9(13)5-3-8/h2-7H,13H2,1H3
52939-06-7Relevant academic research and scientific papers
(5-Arylfuran-2-ylcarbonyl)guanidines as cardioprotectives through the inhibition of Na+/H+ exchanger isoform-1
Lee, Sunkyung,Yi, Kyu Yang,Hwang, Sun Kyung,Lee, Byung Ho,Yoo, Sung-Eun,Lee, Kyunghee
, p. 2882 - 2891 (2007/10/03)
A series of (5-arylfuran-2-ylcarbonyl)guanidines was synthesized and evaluated for the NHE-1 inhibitory activity and cardiprotective efficacy against ischemia-reperfusion injury. Starting with (5-phenylfuran-2-ylcarbonyl) guanidine 47 with a moderate inhibitory effect on NHE-1, the compounds with various substituents at the phenyl ring were investigated with the aim to optimize the potency. In this study, the 2,5-disubstituted compounds appeared to have better activities than the other analogues, and the 2-methoxy-5- chlorophenyl compound 85 was found as a potent inhibitor of NHE-1 (IC 50 = 0.081 μM). Furthermore, 85 showed a marked reduction of infarct size in the rat myocardial infarction model in vivo and significant improvement of cardiac contractile function in the isolated rat heart ischemia model in vitro.
AMINO ACIDS
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Page/Page column 44-46, (2008/06/13)
Compounds of formula (I): Z’ -CO-A-B-NH-Z (I) wherein: Z is H or an amino protecting group; Z’ is OH, a protected or activated hydroxyl group or C1; A is an optionally substituted C5-6 arylene group; and B is an optionally substituted C5-6 arylene group.
