52944-50-0Relevant articles and documents
Hydroformylation and hydrocarbethoxylation of 1,2-dicarbethoxy-1,2,3,6-tetrahydropyridazine and 1,2-dicarbethoxy-1,2,3,4-tetrahydropyridazine
Menchi, G.,Paganelli, S.,Matteoli, U.,Scrivanti, A.,Botteghi, C.
, p. 229 - 235 (1993)
The unsaturated compounds 1,2-dicarbethoxy-1,2,3,6-tetrahydropyridazine 1 and 1,2-dicarbethoxy-1,2,3,4-tetrahydropyridazine 2 have been hydroformylated and hydrocarbethoxylated in the presence of some well known cobalt, rhodium, palladium and platinum catalysts.The hydroformylation reaction can be tuned by a suitable choice of the catalyst precursor and reaction conditions, thus allowing the synthesis with high selectivity of one of the two possible isomeric aldehydes.The carbonylation reaction is less synthetically useful, since it shows low activity andunsatisfactory chemo- and regio-selectivity.However, the ester 1,2,4-tricarbethoxyhexahydropyridazine 10 can be prepared in good yield from olefin 1 by using the complex as the catalyst precursor.
Process for producing hexahydropyridazine and hexahydropyridazine-1,2-dicarboxy derivative
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, (2008/06/13)
The present invention provides a process for producing a hexahydropyridazine-1,2-dicarboxy derivative represented by the general formula: STR1 wherein R1 and R2 represent each independently an alkyl group, by reacting a hydrazinedicarboxy derivative represented by the general formula: wherein R1 and R2 have the same meaning as mentioned above, with a dihalogenobutane represented by the general formula: wherein X1 and X2 represent each independently a halogen atom, in the presence of an alkali metal hydroxide, characterized in that the above reaction is effected in an aprotic polar solvent, and a process for producing a hexahydropyridazine, characterized by decarboxylating the thus obtained hexahydropyridazine-1,2-dicarboxy derivative (3) without isolation in the presence of an alkali metal hydroxide and a hydrogen-denoting compound.
