505-19-1

Basic information

• Product Name: Hexahydropyridazin
• Synonyms: NSC142576;HEXAHYDROPYRIDAZIN;Diazinane;1,2-Diazinane
• CAS NO: 505-19-1
• Molecular Formula: C₄H₁₀N₂
• Molecular Weight: 86.14
• Mol File: 505-19-1.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 107 °C at 760 mmHg
• Flash Point: 10.8 °C
• Appearance: /
• Density: 0.874g/cm³
• Vapor Pressure: 27.6mmHg at 25°C
• Refractive Index: 1.424
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 9.59±0.20(Predicted)
• CAS DataBase Reference: Hexahydropyridazin(CAS DataBase Reference)
• NIST Chemistry Reference: Hexahydropyridazin(505-19-1)
• EPA Substance Registry System: Hexahydropyridazin(505-19-1)

Safety Data

• Hazardous Substances Data: 505-19-1(Hazardous Substances Data)

Usage

General Description

Hexahydropyridazine, also known as cyclohexane-1,2-diamine, is a six-membered heterocyclic compound with a pyridazine ring. Its chemical formula is C4H10N2. It is a clear, colorless liquid with a slightly ammoniacal odor. It is commonly used as a reagent in organic synthesis, particularly in the production of pharmaceuticals and agrochemicals. Hexahydropyridazine is also used as a precursor for the synthesis of various compounds, including heterocyclic derivatives. It is highly reactive and can readily undergo a variety of chemical reactions, such as oxidation, reduction, and substitution. It is also known to have potential neuroprotective and analgesic properties, making it of interest for medicinal and pharmaceutical research.

InChI:InChI=1/C4H10N2/c1-2-4-6-5-3-1/h5-6H,1-4H2

Upstream product

• 75156-22-8 dimethyl 3,4,5,6-tetrahydropyridazine-1,2-dicarboxylate 
• 56-23-5 tetrachloromethane 
• 7732-18-5 water 
• 333-93-7 putrescine dihydrochloride 
• 140200-91-5 1,2,3,6-tetrahydropyridazine-1,2-dicarboxylic acid dibenzyl ester 
• 52944-50-0 tetrahydro-1,2-pyridazinedicarboxylic acid,diethyl ester 
• 5311-96-6 diethyl hydrazinedicarboxylate 
• 110-56-5 1,4-dichlorobutane 
• 340256-13-5 tert-butyl 2-[(tert-butyl)oxycarbonyl]perhydropyridazine-1-carboxylate 
• 68387-96-2 N,N'-diisobutyrylhexahydropyridazine 

Downstream Products

• 5695-03-4 1,2,3,4,6,11-hexahydropyridazino[1,2-b]phthalazine-6,11-dione 
• 123102-66-9 2-(tetrahydro-pyridazine-1-carbonyl)-benzoic acid 
• 5767-21-5 6,13-diphenyloctahydrodipyridazino[1,2-a:1',2'-d]-1,2,4,5-tetrazine 
• 13645-31-3 1,2-dibenzoyl-hexahydro-pyridazine 
• 101741-54-2 tetrahydro-pyridazine-1,2-dicarboxylic acid-dianilide 
• 5721-43-7 hexahydro-pyrazolo[1,2-a]pyridazine 
• 3661-15-2 octahydro-pyridazino[1,2-a]pyridazine 
• 89552-73-8 bis(hexahydro-1-pyridazinyl)thiophosphoric acid O-phenylester 
• 131226-02-3 3-Phenyl-2-((R)-toluene-4-sulfinyl)-hexahydro-pyrazolo[1,2-a]pyridazin-1-one 
• 131226-02-3 1,5-Diaza-3-(S)-p-tolylsulfinyl-4-phenylbicyclo<4.3.0>nonan-2-one 
• 112575-00-5 Hexahydro-1-(4-methoxybenzoyl)pyridazin 
• 76598-25-9 2-oxo-4-phenyl-1,5-diazabicyclo<4.3.0>nonane 
• 329963-00-0 2-(2,6-diethyl-4-methylphenyl)hexahydropyrazolo[1,2-a]pyridazine-1,3-dione 
• 1181082-13-2 (5Z)-4-(1,2-diazinan-1-yl)-5-[(4-fluoro-2-hydroxyphenyl)methylidene]-2,5-dihydro-1,3-thiazol-2-one 

Relevant articles and documents

An ATR-FTIR study on the effect of molecular structural variations on the CO2 absorption characteristics of heterocyclic amines, part II

This paper reports on an ATR-FTIR spectroscopic investigation of the CO2 absorption characteristics of a series of heterocyclic diamines: hexahydropyrimidine (HHPY), 2-methyl and 2,2-dimethylhexahydropyrimidine (MHHPY and DMHHPY), hexahydropyridazine (HHPZ), piperazine (PZ) and 2,5- and 2,6-dimethylpiperazine (2,6-DMPZ and 2,5-DMPZ). By using in situ ATR-FTIR the structure-activity relationship of the reaction between heterocyclic diamines and CO2 is probed. PZ forms a hydrolysis-resistant carbamate derivative, while HHPY forms a more labile carbamate species with increased susceptibility to hydrolysis, particularly at higher CO2 loadings (>0.5 mol CO2/mol amine). HHPY exhibits similar reactivity toward CO2 to PZ, but with improved aqueous solubility. The α-methyl-substituted MHHPY favours HCO3- formation, but MHHPY exhibits comparable CO2 absorption capacity to conventional amines MEA and DEA. MHHPY show improved reactivity compared to the conventional α-methyl- substituted primary amine 2-amino-2-methyl-1-propanol. DMHHPY is representative of blended amine systems, and its reactivity highlights the advantages of such systems. HHPZ is relatively unreactive towards CO 2. The CO2 absorption capacity CA (mol CO 2/mol amine) and initial rates of absorption RIA (mol CO2/mol amine min-1) for each reactive diamine are determined: PZ: CA=0.92, RIA=0.045; 2,6-DMPZ: C A=0.86, RIA=0.025; 2,5-DMPZ: CA=0.88, R IA=0.018; HHPY: CA=0.85, RIA=0.032; MHHPY: CA=0.86, RIA=0.018; DMHHPY: CA=1.1, R IA=0.032; and HHPZ: no reaction. Calculations at the B3LYP/6-31+G* and MP2/6-31+G* calculations show that the substitution patterns of the heterocyclic diamines affect carbamate stability, which influences hydrolysis rates. Copyright

PYRAZOLE DERIVATIVE

A compound represented by Formula (I): wherein Ar1 represents Formula (II): Ar2 represents a 5- or 6-membered aromatic heterocyclic group which may be substituted; and X represents Formula (III): a salt thereof, or a solvate of the compound or the salt. A potent platelet aggregation suppressant which does not inhibit COX-1 and COX-2 is provided.

Aza compounds, pharmaceutical compositions and methods of use

The present invention relates to N-substituted cyclic aza compounds, pharmaceutical compositions comprising such compounds, and methods of their use for effecting neuronal activities.