52947-33-8Relevant academic research and scientific papers
Rhodium(iii)-catalyzed annulation of enamides with sulfoxonium ylides toward isoquinolines
Hong, Chao,Yu, Shuling,Liu, Zhanxiang,Zhang, Yuhong
, p. 11490 - 11494 (2021/03/31)
An efficient rhodium(iii)-catalyzed C-H activation followed by intermolecular annulation between enamides and sulfoxonium ylides has been developed. The transformation proceeds smoothly with a broad range of substrates, affording a series of isoquinoline derivatives in moderate to good yields under additive-free conditions.
Synthesis of Isoquinoline Derivatives via Palladium-Catalyzed C?H/C?N Bond Activation of N-Acyl Hydrazones with α-Substituted Vinyl Azides
Jiang, Huanfeng,Nie, Biao,Ren, Qingyun,Wu, Wanqing,Zeng, Wei,Zhang, Ji,Zhang, Yingjun
, (2020/02/25)
A palladium-catalyzed cyclization of N-acetyl hydrazones with vinyl azides has been developed. Various substituted isoquinolines, including diverse fused isoquinolines can be prepared via this protocol in moderate to good yields. Mechanistic studies suggest that α-substituted vinyl azide serves as an internal nitrogen source. Also, C?H bond activation and C?N bond cleavage have been realized using hydrazone as directing group. (Figure presented.).
Bidentate Directing-Enabled, Traceless Heterocycle Synthesis: Cobalt-Catalyzed Access to Isoquinolines
Zhou, Shuguang,Wang, Mingyang,Wang, Lili,Chen, Kehao,Wang, Jinhu,Song, Chao,Zhu, Jin
supporting information, p. 5632 - 5635 (2016/11/17)
Traceless heterocycle synthesis based on transition-metal-catalyzed C-H functionalization is synthetically appealing but has been realized only in monodentate directing systems. Bidentate directing systems allow for the achievement of high catalytic reactivity without the need for a high-cost privileged ligand. The first bidentate directing-enabled, traceless heterocycle synthesis is demonstrated in the cobalt-catalyzed synthesis of isoquinolines via 2-hydrazinylpyridine-directed C-H coupling/cyclization with alkynes. Convenient directing group installation through a ubiquitously present ketone group allows synthetic elaboration for complex molecules.
Preparation of 1-methyl-3-phenylisoquinoline derivatives from oximes using polyphosphoric esters
Niemczak, Micha?,Czerniak, Kamil,Kopczyński, Tomasz
, p. 1868 - 1873 (2015/03/18)
We show a beneficial new approach to the preparation of 1-methyl-3-phenylisoquinoline derivatives. This method involves heating polyphosphate ester and the appropriate oximes obtained from 3,4-diphenylbut-3-en-2-one derivatives. The isoquinolines were syn
Palladium-catalyzed C-H oxidation of isoquinoline N-oxides: Selective alkylation with dialkyl sulfoxides and halogenation with dihalo sulfoxides
Yao, Bo,Song, Ren-Jie,Liu, Yan,Xie, Ye-Xiang,Li, Jin-Heng,Wang, Meng-Ke,Tang, Ri-Yuan,Zhang, Xing-Guo,Deng, Chen-Liang
, p. 1890 - 1896 (2012/09/22)
A novel palladium-catalyzed C-H oxidation of isoquinoline N-oxides has been developed for regioselectively synthesizing substituted isoquinolines. The method represents the first example of using dialkyl sulfoxides as the alkyl sources for the construction of 1-alkylated isoquinolines. Moreover, the regioselective halogenation of isoquinoline N-oxides is also successful using dihalo sulfoxides as the halide sources. Copyright
Silicon-mediated isoquinoline synthesis: Preparation and stereochemical characterization of 4-hydroxy-3-phenylisoquinolines
Badia, Dolores,Dominguez, Esther,Tellitu, Imanol
, p. 4419 - 4430 (2007/10/02)
The silicon-mediated synthesis of 4-hydroxy-6,7-dimethoxy-3-phenylisoquinoline derivatives is reported. The described procedure implies synthetically useful yields and a high degree of stereoselectivity.
