529484-35-3Relevant academic research and scientific papers
Design and synthesis of ethyl pyrrolidine-5,5-trans-lactams as inhibitors of hepatitis C virus NS3/4A protease.
Slater, Martin J,Andrews, David M,Baker, Graham,Bethell, Susanne S,Carey, Seb,Chaignot, Helene,Clarke, Berwyn,Coomber, Barry,Ellis, Malcolm,Good, Andrew,Gray, Norman,Hardy, George,Jones, Paul,Mills, Gail,Robinson
, p. 3359 - 3362 (2007/10/03)
Using a pyrrolidine-5,5-trans-lactam template, we have designed small, neutral, mechanism-based inhibitors of hepatitis C NS3/4A protease. Compound 11a, with an alpha-ethyl P1 substituent and a Boc-valine substituent at the pyrrolidine nitrogen, has an IC(50)=30 microM.
