5296-23-1

Upstream product

• 106-54-7 p-Chlorothiophenol 
• 106-89-8 epichlorohydrin 

Downstream Products

• 35550-44-8 1-amino-3-(4-chloro-phenylsulfanyl)-propan-2-ol 
• 60377-69-7 3-[3-(4-Chloro-phenylsulfanyl)-2-hydroxy-propoxy]-benzoic acid 
• 60377-70-0 (Z)-3-{4-[3-(4-Chloro-phenylsulfanyl)-2-hydroxy-propoxy]-phenyl}-acrylic acid 
• 60377-72-2 (Z)-3-{3-[3-(4-Chloro-phenylsulfanyl)-2-hydroxy-propoxy]-phenyl}-acrylic acid 
• 36734-62-0 (4-chlorophenylthio)methylthiirane 
• 1309922-50-6 1-(4-chlorobenzenesulfonyl)-3-thiocyanatopropan-2-yl acetate 
• 60377-93-7 3-{4-[3-(4-Chloro-phenylsulfanyl)-2-hydroxy-propoxy]-phenyl}-N-hydroxy-propionamide 
• 60377-71-1 3-{4-[3-(4-Chloro-phenylsulfanyl)-2-hydroxy-propoxy]-phenyl}-propionic acid 
• 937242-05-2 (+/-)-1-(4-chlorophenylsulfanyl)-3-thiocyanatopropan-2-yl acetate 
• 937242-09-6 (S)-(+)-1-(4-chlorophenylsulfanyl)-3-thiocyanatopropan-2-ol 
• 2989-38-0 1-chloro-3-(4-chlorophenylsulfanyl)propan-2-ol 
• 613261-30-6 1-azido-3-((4-chlorophenyl)thio)propan-2-ol 
• 60377-33-5 4-[3-(4-Chloro-phenylsulfanyl)-2-hydroxy-propoxy]-benzoic acid methyl ester 
• 60377-37-9 (E)-3-{3-[3-(4-Chloro-phenylsulfanyl)-2-hydroxy-propoxy]-phenyl}-acrylic acid methyl ester 

Relevant academic research and scientific papers

Facile synthesis of thietanes via ring expansion of thiiranes

Thietanes are pharmaceutically important cores of some biological compounds and intermediates of organic synthesis. Various thietanes were prepared from thiiranes via ring expansion through a reaction with trimethyloxosulfonium iodide in the presence of sodium hydride. The reaction process is a nucleophilic ring-opening reaction of thiiranes with dimethyloxosulfonium methylide, generated from trimethyloxosulfonium iodide and sodium hydride, and subsequent intramolecular displacement (cyclization) of thiolates to the dimethyloxosulfonium moiety. The current method provides a new strategy for efficient preparation of thietanes from readily available thiiranes.

Simple synthesis of β-acetoxy thiocyanates from oxiranes

A convenient and simple method for the preparation of previously unknown β-acetoxy thiocyanates by regioselective ring opening of the corresponding oxiranes with thiocyanate anion followed by acetylation is described. The shorter reaction times, better yields of the products, and easy workup are the advantages of this methodology.

Lipase-catalyzed separation of the enantiomers of 1-substituted-3-arylthio- 2-propanols

Optically active (R)- and (S)-1-substituted-3-(arylthio)propan-2-ols have been prepared in the reaction of the appropriate 2-(arylthiomethyl)oxiranes with chloride and azide anions followed by a lipase-catalyzed transesterification. The effects of the enzyme preparation as well as of the reaction conditions have been compared in terms of the enantiomeric excess of the obtained acetate and unreacted alcohol.