52962-37-5Relevant articles and documents
Palladium catalyzed Suzuki Miyaura cross coupling of 3-chloroisochromen-1-one: Synthesis of glomellin and reticulol analogues
Kumar, Yadavalli Suneel,Dasaradhan, Changalaraya,Prabakaran, Kamalakannan,Manivel, Pitchai,Nawaz Khan, Fazlur-Rahman,Jeong, Euh Duck,Chung, Eun Hyuk
, p. 941 - 945 (2015)
A facile protocol has been developed for a series of 3-substituted isochromen-1-ones utilizing Suzuki coupling strategy. The reaction of 3-chloroisochromen-1one, 1 with different boronic acids utilizing PdCl2(PPh3)2-Ruphos catalytic system gave diversified 3-substituted isochromen-1-ones in excellent yields. The methodology has been utilized in the synthesis of glomellin and reticulol analogues.
Efficient copper-free Pd(OAc)2/Ruphos-catalyzed Sonogashira coupling in the preparation of 3′-hydroxycorfin and gymnopalynes A analogues
Dasaradhan, Changalaraya,Suneel Kumar, Yadavalli,Nawaz Khan, Fazlur-Rahman,Jeong, Euh Duck,Chung, Eun Hyuk
, p. 187 - 191 (2015/02/19)
An efficient method involving copper-free Pd(OAc)2/Ruphos-catalyzed Sonogashira coupling strategy for a variety of 3-alkynyl isochromen-1-ones has been developed. Sonogashira coupling in the presence of catalytic system - Pd(OAc)2/Ruphos, Et3N base, and tetrahydrofuran solvent under aqueous and room temperature conditions, provided novel 3-(alkynyl)-1H-isochromen-1-ones in excellent yields. The methodology has also been extended toward natural isochromen-1-one-3′-hydroxycorfin and gymnopalynes A analogues.
