52978-64-0Relevant academic research and scientific papers
New, regioselective, one-pot synthesis of (all-E)-retinoic acid and analogues from enaminodiester synthons
Cartier, Dominique,Valla, Alain,Le Guillou, Regis,Labia, Roger,Potier, Pierre
, p. 2250 - 2253 (2007/10/03)
A one-pot synthesis of (all-E)-retinoic acid and related compounds from new enamino diester synthons is described. The enamino diesters was produced nearly quantitatively from methyl propylidene- and isopropylidenemalonate and DMF-DMA. This easy process allowed retinoic acid to be produced in 1 d and appeared advantageous to current industrial syntheses. ( Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003).
