52978-83-3

Basic information

• Product Name: 2,3,4-TRIMETHOXY-6-NITROBENZALDEHYDE
• Synonyms: 2,3,4-TRIMETHOXY-6-NITROBENZALDEHYDE
• CAS NO: 52978-83-3
• Molecular Formula: C₁₀H₁₁NO₆
• Molecular Weight: 241.2
• Mol File: 52978-83-3.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 425.078 °C at 760 mmHg
• Flash Point: 203.646 °C
• Appearance: /
• Density: 1.304 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.558
• CAS DataBase Reference: 2,3,4-TRIMETHOXY-6-NITROBENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3,4-TRIMETHOXY-6-NITROBENZALDEHYDE(52978-83-3)
• EPA Substance Registry System: 2,3,4-TRIMETHOXY-6-NITROBENZALDEHYDE(52978-83-3)

Safety Data

• Hazardous Substances Data: 52978-83-3(Hazardous Substances Data)

Usage

General Description

2,3,4-Trimethoxy-6-nitrobenzaldehyde is a chemical compound with the molecular formula C10H11NO5. It is a pale yellow crystalline solid, primarily used as an intermediate in the synthesis of pharmaceuticals, dyes, and other organic compounds. 2,3,4-TRIMETHOXY-6-NITROBENZALDEHYDE is known to exhibit strong antioxidant and antibacterial properties, making it useful in various industrial and research applications. It is also used in the production of fragrances and food flavoring agents due to its aromatic properties. Additionally, 2,3,4-Trimethoxy-6-nitrobenzaldehyde is considered to be relatively stable under normal conditions, making it suitable for long-term storage and handling.

InChI:InChI=1/C10H11NO6/c1-15-8-4-7(11(13)14)6(5-12)9(16-2)10(8)17-3/h4-5H,1-3H3

Upstream product

• 2103-57-3 2,3,4-trimethoxybenzaldehyde 

Downstream Products

• 30448-04-5 4,5,6-trimethoxy-1H-indole 
• 823829-22-7 2,3,4-trimethoxy-6-(4-methoxy-benzylsulfanyl)-benzaldehyde 
• 145182-61-2 2-methyl-3,4,5-trimethoxyaniline 
• 82358-34-7 coeloginin 
• 1360789-67-8 methyl 2-hydroxy-6-iodo-3,4-dimethoxybenzoate 
• 1752-02-9 methyl 6-iodo-2,3,4-trimethoxybenzoate 
• 1334162-97-8 6-iodo-2,3,4-trimethoxybenzoic acid 
• 1448816-22-5 (6-(2-hydroxy-4-methoxyphenyl)-1H-tetrazol-1-yl)-2,3,4-trimethoxyphenol 
• 1448816-31-6 2-(benzyloxy)-N-(2-(benzyloxy)-3,4,5-trimethoxyphenyl)-4-methoxybenzamide 
• 1448816-30-5 2-(benzyloxy)-3,4,5-trimethoxyaniline 
• 1448816-27-0 2-(benzyloxy)-3,4,5-trimethoxy-1-nitrobenzene 
• 1448816-23-6 2,3,4-trimethoxy-6-(5-(4-methoxyphenyl)-1H-tetrazol-1-yl)phenol 
• 1448816-37-2 1-(2-(benzyloxy)-3,4,5-trimethoxyphenyl)-5-(4-methoxyphenyl)-1H-tetrazole 
• 1448816-36-1 1-(2-(benzyloxy)-3,4,5-trimethoxyphenyl)-5-(2-(benzyloxy)-4-methoxyphenyl)-1H-tetrazole 

Relevant articles and documents

Synthesis of Azepino[1,2-a]indole-10-amines via [6+1] Annulation of Ynenitriles with Reformatsky Reagent

Lewis acid-catalyzed [6+1] annulation reactions of 2-cyano-1-propargyl- and 2-alkynyl-1-cyanomethyl-indoles with Reformatsky reagent are described. 8-Aryl, 8-alkyl-, 8-hetaryl-, 9-aryl, and 9-alkyl-azepino[1,2-a]indole amines were obtained through a 7-endo-mode cyclization of the β-aminoacrylate intermediates. The antiproliferative activity of the azepino[1,2-a]indoles analogs against the HCT-116 cells were also examined.

Thiadiazoline- And pyrazoline-based carboxamides and carbothioamides: Synthesis and inhibition against nitric oxide synthase

Two new families of pyrazoline and thiadiazoline heterocycles have been developed. Their inhibitory activities against two different isoforms of nitric oxide synthase (inducible and neuronal NOS) are reported. The novel derivatives were synthesized combining the arylthiadiazoline or arylpyrazoline skeleton and a carboxamide or carbothioamide moiety, used as starting material ethyl 2-nitrobenzoates or substituted nitrobenzaldehydes, respectively. The structure-activity relationships of final molecules are discussed in terms of the R1 radical effects in the aromatic ring, the Y atom in the heterocyclic system, the X heteroatom in the main chain, and the R2 substituent in the carboxamide or carbothioamide rest. In general, thiadiazolines (5a-e) inhibit preferentially the neuronal isoform; among them, 5a is the best nNOS inhibitor (74.11% at 1 mM, IC50 = 420 M). In contrast, pyrazolines (6a-r) behave better as iNOS than nNOS inhibitors, 6m being the best molecule of this series (76.86% at 1 mM of iNOS inhibition, IC50 = 130 M) and the most potent of all tested compounds.

Synthesis and biological evaluation of 4,5-dihydro-1H-pyrazole derivatives as potential nNOS/iNOS selective inhibitors. Part 2: Influence of diverse substituents in both the phenyl moiety and the acyl group

In a preliminary article, we reported a series of 4,5-dihydro-1H-pyrazole derivatives as neuronal nitric oxide synthase (nNOS) inhibitors. Here we present the data about the inhibition of inducible nitric oxide synthase (iNOS) of these compounds. In gener