52999-15-2

Basic information

• Product Name: 3-Butyn-1-ol, 4-(4-methoxyphenyl)-
• Synonyms: 4-(4'-methoxy)phenyl-3-butyn-1-ol;4-anisylbut-3-yn-1-ol;4-(p-methoxyphenyl)-3-butyn-1-ol;4-(4-methoxyphenyl)-but-3-yn-1-ol
• CAS NO: 52999-15-2
• Molecular Formula: C11H12O2
• Molecular Weight: 176.215
• Mol File: 52999-15-2.mol
• Article Data: 32

Chemical Properties

• Melting Point: 65-66 °C
• Boiling Point: 131 °C(Press: 0.750 Torr)
• Density: 1.10±0.1 g/cm3(Predicted)
• CAS DataBase Reference: 3-Butyn-1-ol, 4-(4-methoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Butyn-1-ol, 4-(4-methoxyphenyl)-(52999-15-2)
• EPA Substance Registry System: 3-Butyn-1-ol, 4-(4-methoxyphenyl)-(52999-15-2)

Safety Data

• Hazardous Substances Data: 52999-15-2(Hazardous Substances Data)

Upstream product

• 696-62-8 para-iodoanisole 
• 927-74-2 3-Butyn-1-ol 
• 623-12-1 4-chloromethoxybenzene 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 87639-43-8 4-(4-methoxyphenyl)but-3-yn-1-yl 4-methylbenzenesulfonate 
• 75-21-8 oxirane 
• 768-60-5 4-methoxyphenylacetylen 

Downstream Products

• 689258-50-2 diisopropyl-[4-(4-methoxyphenyl)-3-butynyloxy]silane 
• 1606590-41-3 C₁₉H₁₆O₃ 
• 21690-30-2 (E)-3-(1-(4-methoxyphenyl)ethylidene)dihydro-2(3H)-furanone 
• 92587-78-5 trans-4-(p-methoxyphenyl)-3-buten-1-ol 
• 111168-09-3 (E)-4-Acetoxy-6-(4-methoxy-phenyl)-hex-2-enoic acid methyl ester 
• 111168-10-6 (E)-4-Hydroxy-6-(4-methoxy-phenyl)-hex-2-enoic acid methyl ester 
• 25090-18-0 piperovatine 
• 25090-19-1 methyl (2E,4E)-6-(4-methoxyphenyl)-2,4-hexadienoate 
• 160360-52-1 (R)-6-(4-Methoxy-phenyl)-hex-1-yn-3-ol 
• 864272-92-4 6-(4-methoxy-phenyl)-hex-1-yn-3-ol 
• 56047-51-9 4-(4-methoxyphenyl)butyraldehyde 
• 940288-82-4 4-(p-methoxyphenyl)-3-phenyl-3-buten-1-ol 

Relevant articles and documents

Synthesis of Polysubstituted Fused Pyrroles by Gold-Catalyzed Cycloisomerization/1,2-Sulfonyl Migration of Yndiamides

Yndiamides (bis-N-substituted alkynes) are valuable precursors to azacycles. Here we report a cycloisomerization/1,2-sulfonyl migration of alkynyl-yndiamides to form tetrahydropyrrolopyrroles, unprecedented heterocyclic scaffolds that are relevant to medicinal chemistry. This functional group tolerant transformation can be achieved using Au(I) catalysis that proceeds at ambient temperature, and a thermally promoted process. The utility of the products is demonstrated by a range of reactions to functionalize the fused pyrrole core.

HETEROCYCLIC MITOCHONDRIAL ACTIVITY INHIBITORS AND USES THEREOF

Heterocyclic compounds of Formula (I) and pharmaceutically acceptable salt thereof are disclosed. The use of such heterocyclic compounds and pharmaceutically acceptable salt thereof for the treatment of cancers, and more particularly cancers sensitive to mitochondrial activity inhibition and increased reactive oxygen species (ROS) levels, is also disclosed. Such cancers include acute myeloid leukemia (AML), preferably AML characterized by certain features, such as high level of expression of one or more Homeobox (HOX)-network genes, high and/or low expression of specific genes, the presence of one or more cytogenetic or molecular risk factors such as intermediate cytogenetic risk, Normal Karyotype (A/K), mutated NPM1, mutated CEBPA, mutated FLT3, mutated DNMT3A, mutated TET2, mutated IDH1, mutated IDH2, mutated RUNX1, mutated WT1, mutated SRSF2, intermediate cytogenetic risk with abnormal karyotype (intern(abnK)), trisomy 8 (+8) and/or abnormal chromosome (5/7), and/or a high leukemic stem cell (LSC) frequency.

External Oxidant-Free Oxidative Tandem Cyclization: NaI-Catalyzed Thiolation for the Synthesis of 3-Thiosubstituted Pyrroles

A simple method for the synthesis of 3-thiosubstituted pyrroles from homopropargylic amines and thiosulfonates via a tandem sulfenylation/cyclization has been developed. The thiosulfonates are used both as substrates and oxidants in this transformation. This procedure exhibits good functional group tolerance and a series of 3-thiosubstituted pyrrole derivatives was obtained in moderate to good yields. (Figure presented.).