53-05-4 Usage
Uses
Used in Pharmaceutical Industry:
3alpha,17,21-trihydroxy-5-beta-pregnane-11,20-dione is used as a cortisone derivative for the development of pharmaceutical products. Its application is primarily due to its structural similarity to cortisone, which allows it to mimic or modulate the effects of the hormone in the body. This can be particularly useful in the treatment of various inflammatory and immune-related conditions.
Used in Metabolic Research:
As a normal mammalian metabolite of cortisone, 3alpha,17,21-trihydroxy-5-beta-pregnane-11,20-dione is used in research to study the metabolic pathways and regulatory mechanisms involving cortisone and its related compounds. Understanding the role of this metabolite can provide insights into the broader context of steroid hormone metabolism and its implications in health and disease.
Used in Drug Development:
3alpha,17,21-trihydroxy-5-beta-pregnane-11,20-dione's unique chemical properties and structural features make it a valuable starting point for the development of new drugs targeting specific biological pathways. Researchers can use 3alpha,17,21-trihydroxy-5-beta-pregnane-11,20-dione as a template to design and synthesize novel molecules with improved pharmacological properties, potentially leading to the discovery of new therapeutic agents for various medical conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 53-05-4 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 5 and 3 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 53-05:
(4*5)+(3*3)+(2*0)+(1*5)=34
34 % 10 = 4
So 53-05-4 is a valid CAS Registry Number.
53-05-4Relevant academic research and scientific papers
C-3 GLUCOSIDURONATES OF METABOLITES OF ADRENAL STEROIDS
Mattox, Vernon R.,Goodrich, June E.,Nelson, Albert N.
, p. 23 - 34 (2007/10/02)
On treatment with methyl 2,3,4-tri-O-acetyl-1-bromo-1-deoxy-α-D-glucuronate and silver carbonate, tetrahydrocortisone 21-acetate gave the corresponding 3-glucosiduronate triacetyl methyl ester.This product was converted into the 20-semicarbazone which, by treatment with alkali to hydrolyze the ester functions and acid to hydrolyze the semicarbazone moiety, gave tetrahydrocortisone 3-glucosiduronic acid.The acid was converted into the crystalline barium salt and into the methyl ester.An analogous series of reactions was carried out on tetrahydrocortexolone 21-acetate.Treatment of the 20-semicarbazone of tetrahydrocortisone 3-glucosiduronic acid with potassium borohydride reduced the 11-oxo function to an 11β hydroxyl group; acid-catalyzed removal of the semicarbazone group produced tetrahydrocortisol 3-glucosiduronic acid which also was obtained as the barium salt and the methyl ester.
Process for the production of 3-hydroxy-2-imino-(2H)-pyridinesulphonic acid monohydrate
-
, (2008/06/13)
A process for the production of 3-hydroxy-2-imino-1(2H)-pyridinesulphonic acid comprising oxidation of furfurol and reaction of the oxidation product with sulphamic acid is disclosed which is carried out in the presence of an oxyacid of tri- or pentavalent phosphorus.
