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5-Bromomethyl-3-(4-bromo-phenyl)-isoxazole is a chemical compound with the molecular formula C8H5Br2N2O. It is a derivative of isoxazole, a heterocyclic organic compound consisting of a five-membered ring with one oxygen atom and two nitrogen atoms. The compound features a 5-bromomethyl group (a methyl group with a bromine atom attached) and a 4-bromo-phenyl group (a phenyl group with a bromine atom at the 4-position). This halogenated isoxazole is used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals, particularly those with potential anti-inflammatory, analgesic, and antipyretic properties. Due to its reactive bromine atoms, it can undergo further chemical reactions, making it a valuable building block in organic synthesis.

5300-99-2

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5300-99-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 5300-99-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,3,0 and 0 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 5300-99:
(6*5)+(5*3)+(4*0)+(3*0)+(2*9)+(1*9)=72
72 % 10 = 2
So 5300-99-2 is a valid CAS Registry Number.

5300-99-2Downstream Products

5300-99-2Relevant academic research and scientific papers

A metal-free approach for in situ regioselective synthesis of isoxazoles via 1,3 dipolar cycloaddition reaction of nitrile oxide with propargyl bromide

Aleti, Rajeshwar Reddy,Cherukupalli, Srinivasulu,Dhawan, Sanjeev,Girase, Pankaj S.,Karpoormath, Rajshekhar,Kumar, Vishal,Mohite, Sachin

, (2022/02/01)

Herein, we report a multi-component reaction (MCRs) to synthesise a range of 3-phenyl-5-(bromomethyl)isoxazoles analogues using DMF/water mixture as solvent, providing desired products in good to excellent yields. The reaction efficiently involves the 1,3-dipolar cycloaddition reaction between propargyl bromide and in situ-generated α-chloro aldoximes. The protocol proceeded well under mild metal-free conditions and showed a tolerance for a wide range of substituents. Graphical abstract: [Figure not available: see fulltext.]

Product selectivity of thermal Buchner reaction of methyl 2-(3-arylisoxazol-5-yl)-2-diazoacetates with benzene, naphthalene and mesitylene, and ring-opening/closing reaction of products

Serebryannikova, Anna V.,Galenko, Ekaterina E.,Novikov, Mikhail S.,Khlebnikov, Alexander F.

, (2021/05/04)

Methyl 2-(3-arylisoxazol-5-yl)-2-diazoacetates were synthesized and the product selectivity of their thermal Buchner reaction with benzene, naphthalene and mesitylene was studied. The reaction of the isoxazolyl-substituted diazoacetates with benzene gave

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