53000-96-7

Usage

1-Oxo-1,2-dihydroisoquinoline-4-carbonitrile

A compound consisting of 11 carbon atoms, 8 hydrogen atoms, 2 nitrogen atoms, and 1 oxygen atom.

Chemical structure

Derivative of isoquinoline
A modified version of the isoquinoline core structure, which is a tricyclic aromatic system with two benzene rings fused to a six-membered nitrogen-containing ring.

Contains a nitrile group

A functional group consisting of a carbon atom triple-bonded to a nitrogen atom (-C≡N), which imparts polar and electron-deficient properties to the molecule.

Contains a ketone group

A functional group with a carbonyl group (C=O) bonded to two carbon atoms, which contributes to the molecule's reactivity and ability to form hydrogen bonds.

Medicinal chemistry interest

The compound has potential pharmacological activities, making it a subject of study in the field of drug discovery and pharmaceuticals.

Potential as an antitumor agent

The compound has been researched for its ability to inhibit the growth and spread of cancer cells, making it a candidate for cancer treatment.

Inhibitory effects on certain enzymes

The compound has been studied for its ability to interfere with the function of specific enzymes, which could be useful in the development of enzyme-targeting therapies.

Promising candidate for further research and development

Due to its chemical structure and properties, 1-Oxo-1,2-dihydroisoquinoline-4-carbonitrile is considered a valuable compound for continued investigation in the pursuit of new drugs and therapies.

Upstream product

• 3951-95-9 4-Bromo-1-hydroxyisoquinoline 
• 34846-65-6 isoquinoline-4-carbonitrile 
• 290-87-9 1,3,5-Triazine 
• 5597-04-6 2-cyanomethylbenzoic acid methyl ester 
• 53996-01-3 4-cyanoisoquinoline N-oxide 

Relevant academic research and scientific papers

Light-induced [2 + 2] cycloadditions for the construction of cyclobutane-fused pyridinyl sulfonyl fluorides

Cyclobutanes are an important class of motifs present in a wide range of natural products and other biologically significant molecules. A photocatalytic [2 + 2] cycloaddition between pyridones or isoquinolones and ethenesulfonyl fluoride was achieved, providing a portal to a class of unique cyclobutane-fused pyridinyl sulfonyl fluorides with quaternary rigid rings (30 examples). Further applications of these novel sulfonyl fluoride molecules in SuFEx click chemistry were also accomplished, providing the corresponding sulfonates and sulphonamides with reasonable yields.

A new method using 1,3,5-triazine as an umpolung hydrogen cyanide equivalent toward the syntheses of isoquinolinone and 2-pyridone derivatives

An investigation of Hermecz and Hartenstein's cyclization methods was conducted. Overcoming the limited substrate scope allowed the expansion of the synthetic application of 1,3,5-triazine as an umpolung hydrogen cyanide equivalent. The reaction proceeded under mild conditions to provide various isoquinolinone and 2-pyridone derivatives with excellent yields.

PROLINE DERIVATIVES AND USE THEREOF AS DRUGS

The present invention aims at providing compounds having therapeutic effects due to a DPP-IV inhibitory action, and satisfactory as pharmaceutical products. The present inventors have found that derivatives having a substituent introduced into the γ-position of proline represented by the formula (I) wherein each symbol is as defined in the specification, have a potent DPP-IV inhibitory activity, and completed the present invention by increasing the stability.

Hydroxylation of Nitroarenes with Alkyl Hydroperoxide Anions via Vicarious Nucleophilic Substitution of Hydrogen

Rhone-Poulenc Polska Ltd., ul. Grzybowska 80/82, 00-844 Warszawa, Poland Garbo- and heterocyclic nitroarenes react with anions of tert-butyl and cumyl hydroperoxides in the presence of strong bases to form substituted o- and p-nitrophenols. The reaction usually proceeds in high yields and is of practical value as a method of synthesis and manufacturing of nitrophenols. Orientation of the hydroxylation can be controlled to a substantial extent by selection of the proper conditions. Basic mechanistic features of this process were clarified.