53004-19-6

Basic information

• Product Name: 1H-Benzimidazole-2-carboxaldehyde,5-methoxy-1-methyl-(9CI)
• Synonyms: 1H-Benzimidazole-2-carboxaldehyde,5-methoxy-1-methyl-(9CI);5-Methoxy-1-methylbenzimidazole-2-carboxaldehyde;1H-Benzimidazole-2-carboxaldehyde, 5-methoxy-1-methyl-;5-Methoxy-1-Methyl-1H-benzo[d]iMidazole-2-carbaldehyde;5-methoxy-1-methylbenzimidazole-2-carbaldehyde
• CAS NO: 53004-19-6
• Molecular Formula: C10H10N2O2
• Molecular Weight: 190.2
• Product Categories: BENZIMIDAZOLE
• Mol File: 53004-19-6.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-Benzimidazole-2-carboxaldehyde,5-methoxy-1-methyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Benzimidazole-2-carboxaldehyde,5-methoxy-1-methyl-(9CI)(53004-19-6)
• EPA Substance Registry System: 1H-Benzimidazole-2-carboxaldehyde,5-methoxy-1-methyl-(9CI)(53004-19-6)

Safety Data

• Hazardous Substances Data: 53004-19-6(Hazardous Substances Data)

Usage

General Description

1H-Benzimidazole-2-carboxaldehyde, 5-methoxy-1-methyl-(9CI) is a chemical compound with the molecular formula C11H11N2O2. It is a derivative of benzimidazole, containing a carboxaldehyde and a methoxy group. 1H-Benzimidazole-2-carboxaldehyde,5-methoxy-1-methyl-(9CI) has potential pharmaceutical applications due to its structural properties and may be used in the synthesis of various pharmaceutical drugs. It is important to handle this chemical with caution as it may have certain hazards and should be used only by trained professionals in a controlled laboratory environment.

Upstream product

• 4887-81-4 6-methoxy-2-methyl-1H-benzo[d]imidazole 
• 74-88-4 methyl iodide 
• 20033-99-2 (5-methoxy-1H-benzimidazole-2-yl)-methanol 
• 102-51-2 4-methoxy-1,2-phenylenediamine 
• 68426-83-5 (5-methoxy-1-methyl-1H-benzo[d]imidazol-2-yl)methanol 

Downstream Products

• 1357162-32-3 C₂₀H₁₈N₂O₄ 
• 1357162-41-4 C₂₀H₁₈N₂O₄ 

Relevant articles and documents

PROBES FOR IMAGING HUNTINGTIN PROTEIN

Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use. Formula (I)

Synthesis of substituted benzimidazolyl curcumin mimics and their anticancer activity

A novel curcumin mimic library (14a-14h and 15a-15h) possessing variously substituted benzimidazole groups was synthesized through the aldol reaction of (E)-4-(4-hydroxy-3-methoxyphenyl)but-3-en-2-one (7) or (E)-4-(3-hydroxy-4- methoxyphenyl)but-3-en-2-one (13) with diversely substituted benzimidazolyl-2-carbaldehyde (12a-12h). The MTT assay of the cancer cells MCF-7, SH-SY5Y, HEP-G2, and H460 showed that compound 14c with IC50 of 1.0 and 1.9 μM has a strong inhibitory effect on the growth of SH-SY5Y and Hep-G2 cells, respectively, and that compound 15h with IC50 of 1.9 μM has a strong inhibitory effect on the growth of MCF-7 cancer cells.