53005-58-6

Upstream product

• 2445-83-2 7-methylcoumarin 
• 77-78-1 dimethyl sulfate 
• 74-88-4 methyl iodide 
• 141-82-2 malonic acid 
• 57415-35-7 2-methoxy-4-methylbenzaldehyde 
• 108-39-4 3-methyl-phenol 
• 698-27-1 4-methylsalicylaldehyde 
• 7664-93-9 sulfuric acid 
• 33599-68-7 (E)-3-(2-hydroxy-4-methylphenyl)acrylic acid 

Downstream Products

• 2445-83-2 7-methylcoumarin 
• 53005-62-2 3-(2-methoxy-4-methylphenyl)propanoic acid 
• 133129-38-1 methyl (1,4,8-trimethoxy-3-(2-methoxy-4-methylphenyl)naphthalen-2-yl)carbamate 
• 139976-09-3 methyl 1,4,8-trimethoxy-3-(2-methoxy-4-methylphenyl)naphthalene-2-carboxylate 
• 139976-10-6 1,4,8-trimethoxy-3-(2-methoxy-4-methylphenyl)-2-naphthoic acid 
• 139976-12-8 5,9-Dimethoxy-4-(2-methoxy-4-methyl-phenyl)-3H-1-oxa-3-aza-cyclopenta[a]naphthalen-2-one 
• 139976-04-8 methyl 3-(2-methoxy-4-methylphenyl)-8-methoxy-1,4-naphthoquinone-2-carboxylate 
• 139976-06-0 3-(2-methoxy-4-methylphenyl)-8-methoxy-1,4-naphthoquinone-2-carboxylic acid 
• 139976-08-2 2-amino-3-(2-methoxy-4-methylphenyl)-8-methoxy-1,4-naphthoquinone 
• 139976-07-1 2-hydroxy-3-(2-methoxy-4-methylphenyl)-8-methoxy-1,4-naphthoquinone 
• 139976-11-7 1,4,8-trimethoxy-3-(2-methoxy-4-methylphenyl)naphthalene-2-carboxamide 
• 139976-02-6 methyl 2-methoxy-4-methylcinnamate 

Relevant academic research and scientific papers

Total synthesis of the proposed structure of Anti-TMV active tabasesquiterpene A

The proposed structure of Tabasesquiterpene A, an illudalane type of sesquiterpene has been synthesized in twelve steps from 2-methoxy-4-methylbenzaldehyde in 40% overall yield. Triflic acid mediated intramolecular Freidel-Crafts acylation allows to develop the critical indanone moiety, a key intermediate of this synthesis. A careful ortho-selective formylation and subsequent Knoevenagel condensation to incorporate three carbon side chain, followed by reduction, formation of tricyclic lactone and DIBAL-H supported reduction of lactone to target were other key transformation involved. The NMR spectroscopic data of the synthetic sample differ from those of natural tabasesquiterpene A.