530089-10-2Relevant academic research and scientific papers
Preparation of (4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene)acetamide derivatives as novel arginine vasopressin V2 receptor agonists
Tsukamoto, Issei,Koshio, Hiroyuki,Akamatsu, Seijiro,Kuramochi, Takahiro,Saitoh, Chikashi,Yatsu, Takeyuki,Yanai-Inamura, Hiroko,Kitada, Chika,Yamamoto, Eisaku,Sakamoto, Shuichi,Tsukamoto, Shin-ichi
experimental part, p. 9524 - 9535 (2009/04/05)
The present work describes the discovery of novel series of (4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepine-5-ylidene)acetamide derivatives as arginine vasopressin (AVP) V2 receptor agonists. By replacing the amide juncture in YM-35278 with a direct ring connection gave compound 10a, which acts as a V2 receptor agonist. These studies provided the potent, orally active non-peptidic V2 receptor agonists 10a and 10j.
4,4-DIFLUORO-1,2,3,4-TETRAHYDRO-5H-1-BENZAZEPINE DERIVATIVES OR SALTS THEREOF
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Page 27-28; 29, (2008/06/13)
4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepine derivatives, which have excellent arginine vasopressin V2 activity and are useful for a drug for the treatment of central diabetes insipidus and/or nocturia.
