530112-65-3

Basic information

• Product Name: 2-amino-3-(2-benzyloxybenzoylamino)benzoic acid methyl ester
• Synonyms: 2-amino-3-(2-benzyloxybenzoylamino)benzoic acid methyl ester
• CAS NO: 530112-65-3
• Molecular Weight: 376.412
• Mol File: 530112-65-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-amino-3-(2-benzyloxybenzoylamino)benzoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-3-(2-benzyloxybenzoylamino)benzoic acid methyl ester(530112-65-3)
• EPA Substance Registry System: 2-amino-3-(2-benzyloxybenzoylamino)benzoic acid methyl ester(530112-65-3)

Safety Data

• Hazardous Substances Data: 530112-65-3(Hazardous Substances Data)

Upstream product

• 14389-86-7 2-benzyloxybenzoic acid 
• 107582-20-7 2,3-diaminobenzoic acid methyl ester 
• 530-62-1 1,1'-carbonyldiimidazole 
• 55142-16-0 methyl 2-(benzyloxy)benzoate 
• 606-18-8 3-nitroanthranilic acid 
• 57113-91-4 methyl 3-nitroanthranilate 
• 119-36-8 methyl salicylate 
• 2719-08-6 methyl 2-(acetylamino)benzoate 
• 69-72-7 salicylic acid 

Downstream Products

• 530112-67-5 2-[2-(benzyloxy)phenyl]-1H-benzimidazole-4-carboxylic acid 
• 908371-35-7 2-amino-3-{[2-(2-benzyloxy-phenyl)-1H-benzoimidazole-4-carbonyl]-amino}-benzoic acid methyl ester 
• 908371-36-8 2'-(2-benzyloxy-phenyl)-1H,1'H-[2,4']bibenzoimidazolyl-4-carboxylic acid methyl ester 
• 530112-66-4 methyl 2-[2-(benzyloxy)phenyl]-1H-benzimidazole-4-carboxylate 

Relevant articles and documents

Synthesis and anticancer evaluation of bis(benzimidazoles), bis(benzoxazoles), and benzothiazoles

Four classes of UK-1 analogues were synthesized and their cytotoxicity testing against human A-549, BFTC-905, RD, MES-SA, and HeLa carcinoma cell lines was determined. The results revealed that UK-1 and four of these analogues (15-18) are potent against the cancer cell lines. In particular, compound 16 is more potent than UK-1 against A-549 and HeLa cell lines, and compounds 15, 17, and 18 selectively exhibit potent cytotoxic activity against the BFTV-905 cells (IC50 9.6 μM), A-549 cells (IC50 6.6 μM), and MES-SA cells (IC50 9.2 μM), respectively.

Synthesis and evaluation of anticancer benzoxazoles and benzimidazoles related to UK-1

UK-1 is a structurally unique bis(benzoxazole) natural product isolated from a strain of Streptomyces. UK-1 has been reported to possess anticancer activity but no activity against bacteria, yeast, or fungi. Previous work has also demonstrated the ability