530116-14-4

Usage

Structure

A sulfonyl derivative of 1H-indole with a (2-fluorophenyl)sulfonyl group attached to the 1-position of the indole ring

Unique properties

The presence of the sulfonyl group and the fluorophenyl group contribute to the compound's unique properties and potential applications

Potential applications

Pharmaceutical industry, organic synthesis, and further research and development for biological or medicinal properties

Reactivity

The presence of the fluorophenyl group adds to the compound's reactivity

Building block

The compound may be used as a building block in the synthesis of various pharmaceuticals and organic compounds due to its unique structure and reactivity.

Upstream product

• 2905-21-7 2-fluorobenzenesulfonyl chloride 
• 18344-49-5 1-indolyllithium 
• 120-72-9 indole 

Downstream Products

• 530116-15-5 C₁₄H₉ClFNO₄S₂ 

Relevant academic research and scientific papers

N-SULFONYL INDOLE DERIVATIVE COMPOUND AND USE THEREOF

PROBLEM TO BE SOLVED: To provide an N-sulfonyl indole derivative compound useful for the treatment of cancer and hypertension. SOLUTION: This invention provides an N-sulfonyl indole derivative compound represented by formula (1) where R1 is an aryl group, cycloalkyl group or heteroaryl group, and R2 is Si(R5)(R6)(R7), C1-C6 alkyl group or acetyl group. COPYRIGHT: (C)2016,JPOandINPIT

Expansion of SAR studies on triaryl bis sulfone cannabinoid CB2 receptor ligands

We report further expansion of the structure activity relationship (SAR) on the triaryl bis sulfone class of compounds (I), which are potent CB2 receptor ligands with excellent selectivity over the CB1 receptor. This study was extended to B ring changes, followed by simultaneous optimization of the A-, B-, and C-rings. Compound 42 has excellent CB2 potency, selectivity and rat exposure.

CANNABINOID RECEPTOR LIGANDS

Compounds of Formula (I) and/or pharmaceutically acceptable salts, solvates or prodrugs thereof, or pharmaceutical compositions containing such compounds exhibit anti-inflammatory and immunomodulatory activity, and can be effective asCB2 receptor ligands in treating cancer and inflammatory, immunomodulatory or respiratory diseases or conditions.

CANNABINOID RECEPTOR LIGANDS

There are disclosed compounds of the formula I: or a pharmaceutically acceptable salt of the compound, which exhibit anti-inflammatory and immunomodulatory activity. Also disclosed are pharmaceutical compositions containing said compounds.