530134-86-2Relevant academic research and scientific papers
Discovery and structure-activity relationships of urea derivatives as potent and novel CCR3 antagonists
Nitta, Aiko,Iura, Yosuke,Tomioka, Hiroki,Sato, Ippei,Morihira, Koichiro,Kubota, Hirokazu,Morokata, Tatsuaki,Takeuchi, Makoto,Ohta, Mitsuaki,Tsukamoto, Shin-Ichi,Imaoka, Takayuki,Takahashi, Toshiya
, p. 4951 - 4954 (2012/08/28)
The synthesis and structure-activity relationships of ureas as CCR3 antagonists are described. Optimization starting with lead compound 2 (IC 50 = 190 nM) derived from initial screening hit compound 1 (IC 50 = 600 nM) led to the iden
