530145-62-1 Usage
Uses
Used in Pharmaceutical Industry:
(R)-N-(5-cyano-2-nitrobenzyl)-N-(1-hydroxy-3-phenylpropan-2-yl)thiophene-2-sulfonamide is used as a reactant for the preparation of 3,7-disubstituted-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine compounds. These compounds are significant due to their farnesyl protein transferase inhibitory activity, which can be leveraged in the development of pharmaceuticals targeting various diseases and conditions.
Used in Chemical Synthesis:
In the field of chemical synthesis, (R)-N-(5-cyano-2-nitrobenzyl)-N-(1-hydroxy-3-phenylpropan-2-yl)thiophene-2-sulfonamide serves as a key intermediate in the creation of various complex organic molecules. Its unique structure and reactivity make it a valuable component in the synthesis of specialized chemicals with potential applications in different industries.
Chemical Properties:
(R)-N-(5-cyano-2-nitrobenzyl)-N-(1-hydroxy-3-phenylpropan-2-yl)thiophene-2-sulfonamide is presented as a yellow solid, indicating its stability and potential for use in various chemical processes. Its physical state and color can be important factors in its handling, storage, and application in different settings.
Check Digit Verification of cas no
The CAS Registry Mumber 530145-62-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,3,0,1,4 and 5 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 530145-62:
(8*5)+(7*3)+(6*0)+(5*1)+(4*4)+(3*5)+(2*6)+(1*2)=111
111 % 10 = 1
So 530145-62-1 is a valid CAS Registry Number.
530145-62-1Relevant academic research and scientific papers
Development of a Practical Synthesis of a Farnesyltransferase Inhibitor
Shi, Zhongping,Fan, Junying,Kronenthal, David R.,Mudryk, Boguslaw M.
, p. 1534 - 1540 (2018/11/23)
The development of a new and practical synthesis for a farnesyltransferase inhibitor 1 is described. The new route started from 2-nitro-5-cyanotoluene (9) and afforded desired 1 in eight chemical transformations. The key step involved formation of sulfonamide 13 from a hindered β-hydroxyamine 12 through an in situ protection of the hydroxyl group by forming TMS ether. Ultimately, this new route was successfully demonstrated to generate >10 kg of API in 29% overall yield.
Process for the preparation of 3,7-disubstituted-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine compounds
-
, (2008/06/13)
Methods for the synthesis of benzodiazepine compounds having farnesyl protein transferase inhibitory activity.
