530150-55-1

Upstream product

• 81494-05-5 2-chloro-N-(4-methoxybenzyl)acetamide 
• 2393-23-9 4-methoxy-benzylamine 
• 532422-39-2 C₁₇H₁₇N₃O₂S₂ 
• 98-88-4 benzoyl chloride 

Relevant academic research and scientific papers

Synthesis, structure-activity relationships and preliminary antitumor evaluation of benzothiazole-2-thiol derivatives as novel apoptosis inducers

A series of novel benzothiazole-2-thiol derivatives were synthesized, and their anti-proliferative activities on HepG2 and MCF-7 cells were investigated. Most compounds had inhibitory effects on cell growth, and some of them were more effective than cisplatin. Compounds 6m and 6t displayed good inhibitory activities against a panel of different types of human cancer cell lines, with IC50 values in the low micromolar range. Further biological evaluation indicated that 6m induced apoptosis in HepG2 cancer cells. Structure-activity relationships were also proposed.