5307-06-2

Basic information

• Product Name: Acetamide, N-(4-hydroxy-2-methoxyphenyl)-
• CAS NO: 5307-06-2
• Molecular Formula: C9H11NO3
• Molecular Weight: 181.191
• Mol File: 5307-06-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Acetamide, N-(4-hydroxy-2-methoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, N-(4-hydroxy-2-methoxyphenyl)-(5307-06-2)
• EPA Substance Registry System: Acetamide, N-(4-hydroxy-2-methoxyphenyl)-(5307-06-2)

Safety Data

• Hazardous Substances Data: 5307-06-2(Hazardous Substances Data)

Upstream product

• 106063-48-3 4-benzenesulfonic acid 
• 150-19-6 O-methylresorcine 
• 93-26-5 2-methoxyacetanilide 
• 61638-01-5 4-Amino-3-methoxyphenol 
• 108-24-7 acetic anhydride 

Downstream Products

• 2735-04-8 2,4-Dimethoxyaniline 
• 101908-41-2 2-chloro-N-(2,4-dimethoxyphenyl)acetamide 
• 127285-30-7 4-ethoxy-2-methoxyaniline 
• 23042-75-3 N-(2,4-dimethoxyphenyl)acetamide 
• 5653-22-5 acetic acid-(4-ethoxy-2-methoxy-anilide) 

Relevant articles and documents

Introduction of a hydroxy group at the para position and N-iodophenylation of N-arylamides using phenyliodine(III) bis(trifluoroacetate)

The reaction of anilides with phenyliodine(III) bis(trifluoroacetate) (PIFA) in trifluoroacetic acid (TFA), TFA-CHCl3, or hexafluoroisopropyl alcohol (HFIP) is described. When the acyl group of the anilide is highly electronegative, such as trifluoroacetyl, or the phenyl group is substituted with an electron-withdrawing group, the 4-iodophenyl group is transferred from PIFA to the amide nitrogen to afford acetyldiarylamines. On the other hand, when the acyl group contains an electron-donating function, such as 4-methoxyphenyl, or the phenyl group is substituted with an electron-donating group, a trifluoroacetoxy group is transferred to the para position of the anilide aromatic ring. This group is hydrolyzed during workup to produce the corresponding phenol.