23042-75-3

Basic information

• Product Name: N-(2,4-dimethoxyphenyl)acetamide
• Synonyms: N-(2,4-dimethoxyphenyl)acetamide;EINECS 245-394-7;1-(Acetylamino)-2,4-dimethoxybenzene;2',4'-Dimethoxyacetanilide;Acetamide, N-(2,4-dimethoxyphenyl)-
• CAS NO: 23042-75-3
• Molecular Formula: C₁₀H₁₃NO₃
• Molecular Weight: 195.21512
• EINECS: 245-394-7
• Product Categories: Amines, Aromatics, Miscellaneous Reagents
• Mol File: 23042-75-3.mol
• Article Data: 14

Chemical Properties

• Melting Point: 117 °C(Solv: ethanol (64-17-5))
• Boiling Point: 350.3°Cat760mmHg
• Flash Point: 165.6°C
• Appearance: /
• Density: 1.144g/cm³
• Vapor Pressure: 4.44E-05mmHg at 25°C
• Refractive Index: 1.544
• PKA: 13.90±0.70(Predicted)
• CAS DataBase Reference: N-(2,4-dimethoxyphenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2,4-dimethoxyphenyl)acetamide(23042-75-3)
• EPA Substance Registry System: N-(2,4-dimethoxyphenyl)acetamide(23042-75-3)

Safety Data

• Hazardous Substances Data: 23042-75-3(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 23042-75-3 differently. You can refer to the following data:
1. N-(2,4-dimethoxyphenyl)acetamide has been used as a reactant for the synthesis of regioselective halogenation of aromatic compounds.
2. 2'',4''-Dimethoxyacetanilide has been used as a reactant for the synthesis of regioselective halogenation of aromatic compounds.

InChI:InChI=1/C10H13NO3/c1-7(12)11-9-5-4-8(13-2)6-10(9)14-3/h4-6H,1-3H3,(H,11,12)

Upstream product

• 26053-96-3 4-acetoxy-4'-methoxyazobenzene 
• 75-18-3 dimethylsulfide 
• 128317-40-8 N-methoxy-N-(4-methoxyphenyl)acetamide 
• 2735-04-8 2,4-Dimethoxyaniline 
• 72-89-9 acetylcoenzyme A 
• 61638-01-5 4-Amino-3-methoxyphenol 
• 106063-48-3 4-benzenesulfonic acid 
• 150-19-6 O-methylresorcine 
• 75-36-5 acetyl chloride 
• 108-24-7 acetic anhydride 
• 5307-06-2 N-(4-hydroxy-2-methoxyphenyl)acetamide 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 99075-67-9 thioacetic acid-(2,4-dimethoxy-anilide) 
• 76030-55-2 (2,4-dimethoxyphenyl)methanamine 
• 857950-16-4 2,4-dimethoxy-5-nitroacetanilide 
• 2735-04-8 2,4-Dimethoxyaniline 
• 1381862-04-9 N-acetyl-2-methoxy-p-benzoquinone imine dimethyl acetal 
• 95338-37-7 2-methoxy-p-benzoquinone dimethyl acetal 
• 1446481-87-3 di-μ-tosyloxybis(3,5-dimethoxy-2-acetaminophenyl-2C,O)dipalladium(II) 
• 1411995-56-6 C₂₄H₂₂N₂O₇S₂ 
• 1375463-33-4 C₂₄H₂₂N₂O₈S 

Relevant articles and documents

Evaluation of DIMBOA analogs as antifeedants and antibiotics towards the aphid Sitobion avenae in artificial diets

A total of 25 compounds including benzoxazinones, benzoxazolinones, and N-glyoxylamide derivatives were tested as antifeedants and antibiotics towards the aphid Sitobion avenae in diet bioassays. The antifeedant and mortality indexes increased with the presence of electron-donating groups in the 7 position of the benzoxazinone moiety, the replacement of the oxygen atom by sulfur in the heterocyclic ring, the presence of a hemiacetal instead of an acetal at C-2 of the benzoxazine moiety (and hence the possibility of ring opening), and the presence of a hydroxyl group at C-4 of the benzoxazine moiety (hydroxamic acid) instead of a hydrogen atom (lactam). The results support earlier hypotheses on the chemical bases for the mode of action of these compounds.

Isoxazole sulfonamides compound with BRD4 inhibitory activity and preparation method and application thereof

The invention provides an isoxazole sulfonamide compound with BRD4 inhibitory activity or a pharmaceutically acceptable salt thereof, and the compound has the structural formula shown in the general formula (I). The invention further provides an application of the compound or a pharmaceutically acceptable salt or the pharmaceutical composition in preparation of a medicament for preventing or treating cancer related to BRD4, wherein the cancer comprises leukemia. The lymphoma, myeloma, lung cancer, prostate cancer, pancreatic cancer, colon cancer, breast cancer, liver cancer, gastric cancer, and the like. The invention provides a novel BRD4 inhibitor, and experiments prove that the novel compound has a 3 - ethyl benzo [d] isoxazole sulfonamide structure and has a good BRD4 protein inhibition effect and an in-vitro tumor cell inhibition effect. The compounds can also effectively inhibit the expression of c-Myc oncogenes.

Selective, Catalytic, and Metal-Free Coupling of Electron-Rich Phenols and Anilides Using Molecular Oxygen as Terminal Oxidant

Selective oxidative homo- and cross-coupling of electron-rich phenols and anilides was developed using nitrosonium tetrafluoroborate as a catalyst. Oxidative coupling of phenols revealed unusual selectivities, which translated into the unprecedented synthesis of inverse Pummerer-type ketones. Mechanistic studies suggest that oxidative coupling of phenols and anilides shares a common pathway via homolytical heteroatom-hydrogen bond cleavage. Nitrosonium salt catalysis was applied for cross-dehydrogenative coupling initiated by generation of heteroatom-centered radicals.

A kind of benzo [d] different wicked zuozuo apperception compound and use thereof

The invention relates to the technical field of chemical medicine, and particularly discloses a benzo[d]isoxazole compound shown as a general formula (A) and application thereof. The compound can effectively inhibit bromodomain of BET family proteins so as to block interaction between the BET family proteins and chromatin histone to adjust genetic transcription, cause changing of a downstream signal path and exert important influence on various diseases, so that the compound and a combination thereof can be used for preparing medicine for treating or preventing diseases like tumorigenesis, inflammation, viral infection, cell proliferation disorder, autoimmune diseases and septicemia.