531-82-8

Basic information

• Product Name: furothiazole
• Synonyms: furothiazole;N-(4-(5-NITRO-2-FURYL)-2-THIAZOLYL)ACETAMIDE;N-(4-(5-NITRO-2-FURYL)-THIAZOLYL)ACETAMIDE;NFTA;N-(4-(5-NITRO-2-FURYL)-2-THIAZOYL)ACETAMIDE;N-(4-(5-NITRO-2-FURANYL)-2-THIAZOLYL)-ACETAMIDE;N-[4-(5-Nitro-2-furyl)-2-thiazoly]acetamide;AS-17665
• CAS NO: 531-82-8
• Molecular Formula: C9H7N3O4S
• Molecular Weight: 253.237
• Mol File: 531-82-8.mol
• Article Data: 1

Chemical Properties

• Melting Point: 296 °C (decomp)
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.5590 (rough estimate)
• Refractive Index: 1.6320 (estimate)
• PKA: 9.34±0.50(Predicted)
• CAS DataBase Reference: furothiazole(CAS DataBase Reference)
• NIST Chemistry Reference: furothiazole(531-82-8)
• EPA Substance Registry System: furothiazole(531-82-8)

Safety Data

• Hazardous Substances Data: 531-82-8(Hazardous Substances Data)

Usage

Safety Profile

Suspected carcinogen with experimental carcinogenic, tumorigenic, and neoplastigenic data. Mutation data reported. When heated to decomposition it emits very toxic fumes of SOx, and NOx,.

InChI:InChI=1/C9H7N3O4S/c1-5(13)10-9-11-6(4-17-9)7-2-3-8(16-7)12(14)15/h2-4H,1H3,(H,10,11,13)

Upstream product

• 75884-37-6 2-acetylamino-4-(2-furyl)thiazole 
• 15057-21-3 2-bromo-1-(5-nitro-[2]furyl)-ethanone 
• 5275-69-4 5-nitro-2-acetylfuran 
• 108-24-7 acetic anhydride 
• 91589-12-7 4-(5-nitro-furan-2-yl)-thiazol-2-ylamine; hydrobromide 
• 38514-71-5 2-amino-4-(5-nitro-2-furyl)thiazole 
• 591-08-2 acetylthiourea 

Downstream Products

• 51948-56-2 2-Acetamido-5-brom-4-<5-nitro-2-furyl>-thiazol 

Relevant articles and documents

Thiocyanation, halogenation, dehalogenation, transhalogenation, and nitration of 2-substituted 4-(2-furyl)thiazoles

Bromination and thiocyanation of 2-amino- and 2-acetylamino-4-(2-furyl)thiazoles when 1 mol of reagent is used at 10°C are directed to the 5 position. Formation of 5′-bromo-substituted derivatives when the reaction temperature is raised is the result of a secondary, thermodynamically controlled process. Monohalogenation and mononitration of 4-(2-furyl)-2-methylthiazole are directed to the 5′ position. Nitration of 2-acetylamino-4-(5-nitro-2-furyl)thiazole by a nitrating mixture is accompanied by oxidative cleavage of the 5-nitrofuran moiety and leads to formation of 5,5′- and 3′,5′-dinitro derivatives.