5310-20-3

Basic information

• Product Name: Ethanethioamide, N-(4-chlorophenyl)-
• CAS NO: 5310-20-3
• Molecular Formula: C8H8ClNS
• Molecular Weight: 185.677
• Mol File: 5310-20-3.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Ethanethioamide, N-(4-chlorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanethioamide, N-(4-chlorophenyl)-(5310-20-3)
• EPA Substance Registry System: Ethanethioamide, N-(4-chlorophenyl)-(5310-20-3)

Safety Data

• Hazardous Substances Data: 5310-20-3(Hazardous Substances Data)

Upstream product

• 926-67-0 O-Ethyl thioacetate 
• 36797-15-6 phenyl dithioacetate 
• 106-47-8 4-chloro-aniline 
• 193765-62-7 4-methylphenyl dithioacetate 
• 193765-63-8 4-chlorophenyl dithioacetate 
• 193765-64-9 4-bromophenyl dithioacetate 
• 99-91-2 para-chloroacetophenone 
• 1956-39-4 4-chloroacetophenone oxime 
• 2131-55-7 4-Chlorophenyl isothiocyanate 
• 61694-04-0 2-acetyl-N-(4-chloro-phenyl)-3-thio-malonamic acid ethyl ester 
• 1956-39-4 (E)-1-(4-chlorophenyl)ethanone oxime 
• 98-09-9 benzenesulfonyl chloride 
• 539-03-7 N-(4-chlorophenyl)acetamide 
• 917-64-6 methyl magnesium iodide 

Downstream Products

• 142506-32-9 (R,S)-N-(4-chlorophenyl)-2-(1-hydroxy-1,2,3,4-tetrahydro-1-naphthyl)thioacetamide 
• 1307292-80-3 (4-chloro-phenyl)-[6-isopropylidene-tetrahydro-thiopyran-2-ylidene]-amine 
• 1307292-83-6 (4-chloro-phenyl)-{6-isopropylidene-3-[1-phenylsulfanyl-(E)-methylidene]-tetrahydro-thiopyran-(2Z)-ylidene}-amine 
• 1307292-79-0 6-methyl-5-heptenethioic acid (4-chloro-phenyl)-amide 
• 1307292-82-5 {3-[1-chloro-(E)-methylidene]-6-isopropylidene-tetrahydro-thiopyran-(2Z)-ylidene}-(4-chloro-phenyl)-amine 
• 1307292-81-4 2-(4-chloro-phenylamino)-6-isopropylidene-5,6-dihydro-4H-thiopyran-3-carbaldehyde 
• 40746-62-1 1-(4'-chlorophenyl)-5-methyl-1H-tetrazole 
• 142506-33-0 N-(4-chlorophenyl)-2-(3,4-dihydro-1-naphthyl)thioacetamide 
• 142506-34-1 N-(4-chlorophenyl)-2-(1-naphthyl)thioacetamide 
• 539-03-7 N-(4-chlorophenyl)acetamide 

Relevant articles and documents

Contribution of Solvents to Geometrical Preference in the Z/ E Equilibrium of N-Phenylthioacetamide

We studied the Z/E preference of N-phenylthioacetamide (thioacetanilide) derivatives in various solvents by means of 1H NMR spectroscopy, as well as molecular dynamics (MD) and other computational analyses. Our experimental results indicate that the Z/E isomer preference of secondary (NH)thioamides of N-phenylthioacetamides shows substantial solvent dependency, whereas the corresponding amides do not show solvent dependency of the Z/E isomer ratios. Detailed study of the solvent effects based on molecular dynamics simulations revealed that there are two main modes of hydrogen (H)-bond formation between solvent and (NH)thioacetamide, which influence the Z/E isomer preference of (NH)thioamides. DFT calculations of NH-thioamide in the presence of one or two explicit solvent molecules in the continuum solvent model can effectively mimic the solvation by multiple solvent molecules surrounding the thioamide in MD simulations and shed light on the precise nature of the interactions between thioamide and solvent. Orbital interaction analysis showed that, counterintuitively, the Z/E preference of NH-thioacetamides is mainly determined by steric repulsion, while that of sterically congested N-methylthioacetamides is mainly determined by thioamide conjugation.

Organocatalytic, difluorocarbene-based S-difluoromethylation of thiocarbonyl compounds

Upon treatment with trimethylsilyl 2,2-difluoro-2-fluorosulfonylacetate (TFDA) and a catalytic amount of N,N,N′,N′-tetramethyl-1,8-diaminonaphthalene, secondary thioamides and thiocarbamates undergo selective difluoromethylation on the sulfur atom to give S-difluoromethyl thioimidates and thioiminocarbonates in good yields, respectively. This is the first report on the synthesis of acyclic difluoromethyl thioimidates and thioiminocarbonates. The key for S-difluoromethylation is the organocatalytic generation of difluorocarbene (:CF2) under mild conditions, which prevents decomposition of the substrates. This process provides an efficient approach to pharmaceuticals and agrochemicals bearing a difluoromethylsulfanyl group, starting from widely available thiocarbonyl compounds.

O,O-Diethyl dithiophosphoric acid mediated direct synthesis of thioamides from aldehydes and ketones

A general and convenient method for a one-pot conversion of aldehydes and ketones into thioamides has been developed. The protocol involves oximation of aldehydes and ketones followed by deoxygenative thioamidation of oximes with O,O-diethyl dithiophosphoric acid which acts as an acid as well a source of sulfur. The method is operationally simple, high yielding, and also applicable to the conversion of amides and nitriles into the corresponding thioamides.