53103-37-0Relevant academic research and scientific papers
Development of Transition-Metal-Free Lewis Acid-Initiated Double Arylation of Aldehyde: A Facile Approach Towards the Total Synthesis of Anti-Breast-Cancer Agent
Kumar Hazra, Chinmoy,Mahato, Rina,Sharma, Pragya,Singh, Sanjay,Vodnala, Nagaraju,Yadav, Naveen
supporting information, (2022/02/19)
This work describes a mild and robust double hydroarylation strategy for the synthesis of symmetrical /unsymmetrical diaryl- and triarylmethanes in excellent yields using Lambert salt (0.2–1.0 mol%). Despite the anticipated challenges associated with controlling selective product formation, unsymmetrical diaryl- and triarylmethanes products are obtained unprecedentedly. A highly efficient gram scale reaction has also been reported (TON for symmetrical product=475 and for unsymmetrical product=390). The synthetic utility of the methodology is demonstrated by the preparation of several unexplored diaryl- and triarylmethane-based biologically relevant molecules, such as arundine, vibrindole A, turbomycin B, and certain anti-inflammatory agents. A total synthesis of an anti-breast-cancer agent is also demonstrated. Control experiments, Hammett analysis, HRMS and GC-MS studies reveal the reaction intermediates and reaction mechanism.
Synthesis and sulfonation of poly(aryl ethers) containing triphenyl methane and tetraphenyl methane moieties from isocynate-masked bisphenols
Wang,Meng,Wang,Shang,Li,Hay
, p. 3151 - 3158 (2007/10/03)
Wholly aromatic poly(aryl ethers) containing triphenylmethane and tetraphenylmethane moieties were successfully synthesized by aromatic nucleophilic substituting polycondensation from masked bisphenols and decafluorobiphenyl followed by sulfonation with chlorosulfonic acid. The sulfonation took place only at the para positions on the pendant phenyl rings due to the novel biphenol structures designed. For the synthesized polymers, the sulfonation content can be easily controlled and the water-takeup can be conveniently tailored by changing the amount of sulfonation agent. These sulfonated polymers are soluble in polar organic solvents, such as NMP, dimethylacetamide, dimethyl sulfoxide, dimethylformamide, and ethylene glycol monomethyl ether and can be readily cast into tough and smooth films from solutions. The films exhibited very high water absorption ability and superior mechanical strength. These polymers also showed high glass transition temperatures ranging from 176 to 203°C compared with Nafion. The sulfonated polymers can be potentially used as the proton-exchange membranes for fuel cells.
