53103-81-4Relevant academic research and scientific papers
Synthesis and antibacterial activity of 5-methylphenanthridium derivatives as FtsZ inhibitors
Liu, Fang,Venter, Henrietta,Bi, Fangchao,Semple, Susan J.,Liu, Jingru,Jin, Chaobin,Ma, Shutao
, p. 3399 - 3402 (2017/07/07)
5-Methylphenanthridium derivatives were designed, synthesized and evaluated for their in vitro antibacterial activity and cell division inhibitory activity against various Gram-positive and -negative bacteria. Among them, compounds 5A2, 5B1, 5B2, 5B3, 5C1 and 5C2 displayed the best on-target antibacterial activity with an MIC value of 4?μg/mL against B. subtilis ATCC9372 and S. pyogenes PS, showing over 2-fold better activity than sanguinarine. The SARs showed that the 5-methylphenanthridium derivatives with the alkyl side chains at the 2-postion, especially the straight alkyl side chains exerted better on-target antibacterial activity.
Direct arylation under catalysis of an oxime-derived palladacycle: Search for a phosphane-free method
Zhang, Guofu,Zhao, Xiaobao,Yan, Yunbing,Ding, Chengrong
, p. 669 - 672 (2012/03/27)
A phosphane-free method for the direct arylation of benzothiazole by employing oxime-derived palladacycle 1 as a catalyst was developed. The new catalyst system can be used for 2-arylations by using aryl bromides and iodides. In addition, this method is especially suitable for the intramolecular direct coupling of bromo-and iodoamides, as well aschloroamides, to achieve a rapid synthesis of benzo[c]phenanthridine alkaloids. Direct arylation reactions under catalysis of an oxime-derived palladacycle were investigated. This phosphane-free method is applicable for the 2-arylation of benzothiazole and is especially suitable for the intramolecular direct coupling of bromo-and iodoamides, as well as chloroamides, to achieve rapid synthesis of benzo[c]phenanthridine alkaloids. Copyright
