53103-83-6Relevant academic research and scientific papers
Br?nsted acid-promoted hydroamination of unsaturated hydrazones: access to biologically important 5-arylpyrazolines
He, Han,Xu, Ning,Zhang, Honglin,Chen, Bin,Hu, Zhengnan,Guo, Kang,Chun, Jianlin,Cao, Shujun,Zhu, Yingguang
, p. 17340 - 17345 (2021/05/25)
A novel and efficient Br?nsted acid-promoted hydroamination of hydrazone-tethered olefins has been developed. A variety of pyrazolines have been easily obtained in good to excellent yields with high chemo- and regioselectivity under simple and mild conditions. This method represents a straightforward, facile, and practical approach toward biologically important 5-arylpyrazolines, which are difficult to access by previously reported radical hydroamination of β,γ-unsaturated hydrazones.
Synthesis, structure, and properties of 1,3,5-triarylpyridazines
Potikha,Kovtunenko,Turov
experimental part, p. 815 - 822 (2010/04/02)
Treatment of γ-bromodypnone with arylhydrazines gives differently structured products, i.e. γ-bromo-dypnone hydrazones, 1-aryl-3,5-diphenyl- 1,4-dihydropyridazines, 1-aryl-3,5-diphenyl-1,6-dihydro-pyridazines, and aromatic 1,3,5-triarylpyridazinium salts.
Two-step synthesis of β-alkyl chalcones and their use in the synthesis of 3,5-diaryl-5-alkyl-4,5-dihydropyrazoles
Cox, Christopher D.,Breslin, Michael J.,Mariano, Brenda J.
, p. 1489 - 1493 (2007/10/03)
We report a simple and efficient two-step synthesis of variously substituted β-alkyl chalcones (7) from the corresponding Weinreb amide and a terminal alkyne, and that these chalcones are useful intermediates for the synthesis of medicinally interesting 3,5-diaryl-5-alkyl-4,5-dihydropyrazoles (6). The current methodology allows for the incorporation of many substitution patterns not available from the few previously reported approaches to compounds in this class.
ONE-ELECTRON OXIDATION OF 1,3,5-TRIARYL-2-PYRAZOLINES BY ANTIMONY PENTACHLORIDE
Morkovnik, A. S.,Okhlobystin, O. Yu.
, p. 461 - 464 (2007/10/02)
Upon reaction of 1,3,5-triphenyl- and 1,3,5-triphenyl-5-methyl-2-pyrazolines with antimony pentachloride in acetonitrile they undergo oxidation to cation radicals, which subsequently undergo rapid dimerization at the para positions of the N-phenyl groups.
