53114-00-4

Usage

Molecular Structure

A derivative of pyridine with an amine and benzyl group attached.

Primary Uses

Organic synthesis, pharmaceutical research.

Versatility

A valuable building block for creating a variety of compounds.

Therapeutic Applications

Potential anti-cancer agent, targeting specific receptors in cancer cells.

Materials Science

Investigated for its role in the development of new polymers and liquid crystalline materials.

Upstream product

• 115177-61-2 2-(o-azidobenzyl)pyridine 
• 13347-70-1 2-(4'-Amino-2'-nitrobenzyl)pyridin 
• 1151-97-9 2-(2,4-dinitrobenzyl)pyridine 
• 552-89-6 2-nitro-benzaldehyde 
• 115177-58-7 (2-nitrophenyl)(pyridin-2-yl)methanol 
• 109-04-6 2-bromo-pyridine 
• 115177-59-8 (2-aminophenyl)(pyridin-2-yl)methanol 
• 13347-69-8 2-(2-nitrobenzyl)pyridine 

Downstream Products

• 115177-61-2 2-(o-azidobenzyl)pyridine 
• 115177-69-0 2-(2-amino-5-chlorobenzyl)pyridine 

Relevant academic research and scientific papers

INTRAMOLECULAR NITRENE INSERTIONS INTO AROMATIC AND HETEROAROMATIC RINGS. PART 8. FLASH VACUUM PYROLYSIS OF 2-AZIDOBENZYLPYRIDINES

Flash vacuum pyrolysis of 2-azidobenzylpyridines (9)-(11) at temperatures from 350 to 700 deg C gave mixtures of benzonaphthyridines and their dihydro derivatives as major products.The 3-pyridyl derivative (10) also gave 2-(3-cyanoprop-1-enyl)indole (19).Benzonaphthyridines were also obtained by pyrolysis of 2-aminophenyl(x-pyridyl)methanols (4), (5), and (6), .Treatment of the azides (9)-(11) with aluminium chloride gave the corresponding 2-amino-5-chlorobenzylpyridines (21)-(23).The mechanism of the reaction is discussed.

EXPANSION OF A PYRIDINE RING BY A NITRENE

Pyrolysis of 2-(o-azidobenzyl)pyridine (3) gives 3H-1,2-diazepinoindole (5), in which the intermediate nitrene has expanded the pyridine ring.