115177-69-0

Upstream product

• 115177-61-2 2-(o-azidobenzyl)pyridine 
• 733008-44-1 2-(5-chloro-2-nitrobenzyl)pyridine 
• 53114-00-4 2-(2-aminobenzyl)pyridine 
• 109-04-6 2-bromo-pyridine 
• 552-89-6 2-nitro-benzaldehyde 
• 115177-58-7 (2-nitrophenyl)(pyridin-2-yl)methanol 
• 115177-59-8 (2-aminophenyl)(pyridin-2-yl)methanol 

Downstream Products

• 945483-68-1 N-[4-Chloro-2-(pyridin-2-ylmethyl)-phenyl]-3,4-dimethoxybenzenesulfonamide 

Relevant academic research and scientific papers

SULFONAMIDE DERIVATIVES, PREPARATION THEREOF AND USE THEREOF AS ANTAGONISTS OF OREXIN 2 RECEPTORS

The present invention is directed to a compound of formula (I): wherein Ar1, Ar2, Ar3, R1 and T are as defined herein, its preparation, pharmaceutical composition and uses as orexin 2 receptor antagonist.

SULPHONAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

Disclosed are compounds having the general formula (I) as defined herein, the preparation thereof, and the use thereof for the prophylaxis or treatment of any disease involving a dysfunction associated with the orexin 2 receptor such as obesity, appetite or taste disorders including cachexia, anorexia and bulimia, diabetes, metabolic syndromes, vomiting and nausea, depression and anxiety, addictions, mood and behaviour disorders, schizophrenia, sleep disorders, restless legs syndrome, memory learning disorders, sexual and psychosexual dysfunctions, pain, visceral or neuropathic pain, hyperalgesia, allodynia, digestive disorders, irritable bowel syndrome, neuronal degenerescence, ischaemic or haemorrhagic attacks, Cushing's disease, Guillain-Barré syndrome, myotonic dystrophy, urinary incontinence, hyperthyroidism, pituitary function disorders, hypertension or hypotension.

INTRAMOLECULAR NITRENE INSERTIONS INTO AROMATIC AND HETEROAROMATIC RINGS. PART 8. FLASH VACUUM PYROLYSIS OF 2-AZIDOBENZYLPYRIDINES

Flash vacuum pyrolysis of 2-azidobenzylpyridines (9)-(11) at temperatures from 350 to 700 deg C gave mixtures of benzonaphthyridines and their dihydro derivatives as major products.The 3-pyridyl derivative (10) also gave 2-(3-cyanoprop-1-enyl)indole (19).Benzonaphthyridines were also obtained by pyrolysis of 2-aminophenyl(x-pyridyl)methanols (4), (5), and (6), .Treatment of the azides (9)-(11) with aluminium chloride gave the corresponding 2-amino-5-chlorobenzylpyridines (21)-(23).The mechanism of the reaction is discussed.