53119-23-6

Basic information

• Product Name: N-methyl-N-(thiophen-2-ylmethyl)aniline
• Synonyms: N-methyl-N-(thiophen-2-ylmethyl)aniline
• CAS NO: 53119-23-6
• Molecular Weight: 203.308
• Mol File: 53119-23-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-methyl-N-(thiophen-2-ylmethyl)aniline(CAS DataBase Reference)
• NIST Chemistry Reference: N-methyl-N-(thiophen-2-ylmethyl)aniline(53119-23-6)
• EPA Substance Registry System: N-methyl-N-(thiophen-2-ylmethyl)aniline(53119-23-6)

Safety Data

• Hazardous Substances Data: 53119-23-6(Hazardous Substances Data)

Upstream product

• 1003-09-4 2-bromothiophene 
• 100-61-8 N-methylaniline 
• 98-03-3 thiophene-2-carbaldehyde 
• 527-72-0 2-thiophenylcarboxylic acid 

Relevant articles and documents

Aza-Matteson Reactions via Controlled Mono-and Double-Methylene Insertions into Nitrogen-Boron Bonds

Boron-homologation reactions represent an efficient and programmable approach to prepare alkylboronates, which are valuable and versatile synthetic intermediates. The typical boron-homologation reaction, also known as the Matteson reaction, involves formal carbenoid insertions into C-B bonds. Here we report the development of aza-Matteson reactions via carbenoid insertions into the N-B bonds of aminoboranes. By changing the leaving groups of the carbenoids and altering Lewis acid activators, selective mono- and double-methylene insertions can be realized to access various α- and β-boron-substituted tertiary amines, respectively, from common secondary amines. The derivatization of complex amine-containing bioactive molecules, diverse functionalization of the boronate products, and sequential insertions of different carbenoids have also been achieved.

Direct N-Alkylation/Fluoroalkylation of Amines Using Carboxylic Acids via Transition-Metal-Free Catalysis

A scalable protocol of direct N-mono/di-alkyl/fluoroalkylation of primary/secondary amines has been constructed with various carboxylic acids as coupling agents under the catalysis of a simple air-tolerant inorganic salt, K3PO4. Advantageous features include 100 examples, 10 drugs and drug-like amines, fluorinated complex tertiary amines, gram-scale synthesis and isotope-labelling amine, thus demonstrating the potential applicability in industry of this methodology. The involvement of relatively less reactive silicon-hydride compared with the traditional reactive metal-hydride or boron-hydride species required to reduce the amide intermediates presumably contributes to the remarkable functional group compatibility. (Figure presented.).