531500-48-8 Usage
Uses
(6S,12bR)-6-(1,3-Benzodioxol-5-yl)-2,3,7,12b-tetrahydro-2-methyl-pyrazino[1',2':1,5]pyrrolo[3,4-b]quinoline-1,4,12(6H)-trione is tetracyclic pyrroloquinolone derivative and is known to be a potential phosphodiesterase 5 inhibitor.
Check Digit Verification of cas no
The CAS Registry Mumber 531500-48-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,3,1,5,0 and 0 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 531500-48:
(8*5)+(7*3)+(6*1)+(5*5)+(4*0)+(3*0)+(2*4)+(1*8)=108
108 % 10 = 8
So 531500-48-8 is a valid CAS Registry Number.
531500-48-8Relevant articles and documents
Synthesis and SAR of tetracyclic pyrroloquinolones as phosphodiesterase 5 inhibitors
Jiang, Weiqin,Alford, Vernon C.,Qiu, Yuhong,Bhattacharjee, Sheela,John, T. Matthew,Haynes-Johnson, Donna,Kraft, Patricia J.,Lundeen, Scott G.,Sui, Zhihua
, p. 1505 - 1515 (2007/10/03)
The synthesis of the fused tetracyclic pyrroloquinolones 9a-i in four steps is described. The PDE5 inhibitory activities of these compounds, their selectivities against PDE1, PDE2, PDE3, PDE4 and PDE6, the preclinical pharmacokinetic assessments and the in vivo efficacy in increasing intracavernosal pressure are presented and discussed.
