Welcome to LookChem.com Sign In|Join Free
  • or

171596-29-5

Post Buying Request

171596-29-5 Suppliers

Recommended suppliersmore

Product FOB Price Min.Order Supply Ability Supplier
tadanafil and sildenafil powder CAS 171596-29-5
Cas No: 171596-29-5
USD $ 4.0-10.0 / Gram 10 Gram 1000 Metric Ton/Week HUBEI AOKS BIO-TECH CO.,LTD Contact Supplier
High quality Tadalafil
Cas No: 171596-29-5
USD $ 1.0-1.0 / Kilogram 1 Kilogram 3000 Metric Ton/Month Qingdao Sigma Chemical Co., Ltd. Contact Supplier
High purity 99% Cialis Tadalafil Tablet 20mg and Raw Material in stock with fast and safe shipping way CAS NO.171596-29-5
Cas No: 171596-29-5
USD $ 1.0-1.0 / Gram 1 Gram 1 Metric Ton/Day Guangzhou XinKe Chemical Co., LTD Contact Supplier
Tadalafil/ CAS 171596-29-5/ Tadalafil powder
Cas No: 171596-29-5
USD $ 380.0-400.0 / Kilogram 1 Kilogram 4000 Metric Ton/Day Kono Chem Co.,Ltd Contact Supplier
High purity 99% Cialis Tadalafil Tablet 20mg and Raw Material in stock with fast and safe shipping way
Cas No: 171596-29-5
No Data 1 Kilogram 1 Metric Ton/Month Shaanxi Mingqi Chemical Co., Ltd Contact Supplier
High purity Tadalafil Male Sex Hormones 99%
Cas No: 171596-29-5
USD $ 1.0-1.0 / Gram 100 Gram 10000 Kilogram/Year Shanghai Upbio Tech Co.,Ltd Contact Supplier
Tadalafil / Cialis Male Sex Enhance Powder 171596-29-5 CAS NO.171596-29-5
Cas No: 171596-29-5
USD $ 1.0-1.0 / Gram 1 Gram 1 Metric Ton/Month Shaanxi WuZhiYuan Biological Technology Co.,Ltd Contact Supplier
tadalafil
Cas No: 171596-29-5
No Data 500 Gram 100 Kilogram/Month biochem-lab.org Contact Supplier
Tadalafil
Cas No: 171596-29-5
No Data 100 Gram 2500 Kilogram/Month Changzhou Sunsanta Chemical Co.,Ltd Contact Supplier
Cialis Tadanafil cas 171596-29-5
Cas No: 171596-29-5
USD $ 2.0-2.0 / Metric Ton 10 Metric Ton 2000 Metric Ton/Day Hebei Minshang Biotechnology Co., Ltd Contact Supplier

171596-29-5 Usage

Warnings and precautions

Patients currently taking nitrates, experiencing angina pectoris, suffering from heart disease, patients who have unregulated hypertension or hypotension, or patients who have had a stroke in the past 6 months should not take Cialis.

Indications and uses

Cialis (or Tadalafil) was developed by American pharmaceutical company Lilly. It is used to treat erectile dysfunction and belongs to a second generation of PDE5 inhibitors. Studies show that Cialis works very quickly, taking effect in around 15-20 minutes, and has a prolonged effect that can last for up to 36 hours. T1/2 is 17.5h.

Clinical Research

In a study of 348 cases of mild to severe erectile dysfunction, patients were randomly given 20mg of Cialis or a placebo. Results showed that in comparison to the placebo group, patients who took Cialis experienced improved intercourse success in the 24-36 hours following medication, with many patients achieving successful sexual intercourse twice in 36 hours. Side effect rate and severity were also no different from those of the placebo group. Over 5% of patients in the Cialis group experienced headaches and indigestion.

Definition

ChEBI: A pyrazinopyridoindole that is 2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione substituted at position 2 by a methyl group and at position 6 by a 1,3-benzodioxol-5-yl group (the 6R,12aR

Description

Tadalafil (market name “Cialis” or “Adcirca”) is a kind of PDE5 inhibitor used for the treatment of erectile dysfunction, benign prostatic hypertrophy and pulmonary arterial hypertension. The effect of Tadalafil is relaxing the blood vessels muscles and increasing the blood flow into the corpus cavernosum. The mechanism of action of tadalafil is through inhibiting the activity of the cGMP specific phosphodiesterase type 5 (PDE5). PDE5 degrades cGMP in the corpus cavernosum located around the penis. Therefore, tadalafi leads to the increased concentration of cGMP which further causes the smooth muscle relaxation and increased blood flow into the corpus cavernosum. Some clinical studies also implied that tadalafil could improve endothelia function in men with increased cardiovascular risk and lower the urinary tract symptoms secondary to benign prostatic hyperplasia.

Side effects

No severe negative reactions. No perceived facial flushing or sight abnormalities following medication. Rare cases of headache and indigestion.

Uses

analgesic, norepinephrine uptake blocker, mu-opiod receptor agonist

Chemical Properties

White to Off-White Cyrstalline Solid

References

https://www.drugs.com/tadalafil.html
https://www.drugbank.ca/drugs/DB00820
Roehrborn, C. G., et al. "Tadalafil administered once daily for lower urinary tract symptoms secondary to benign prostatic hyperplasia: a dose finding study." Journal of Urology 180.4(2008):1228.
Rosano, Giuseppe M. C., et al. "Chronic Treatment with Tadalafil Improves Endothelial Function in Men with Increased Cardiovascular Risk." European Urology 47.2(2005):214-222.

Brand name

Cialis (Lilly).
InChI:InChI=1/C22H23N3O3/c1-24-8-9-25-17(22(24)26)11-15-14-4-2-3-5-16(14)23-20(15)21(25)13-6-7-18-19(10-13)28-12-27-18/h2-7,10,15,17,20-21,23H,8-9,11-12H2,1H3/t15?,17-,20?,21-/m1/s1

171596-29-5 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Sigma-Aldrich (Y0001417)  Tadalafil  European Pharmacopoeia (EP) Reference Standard 171596-29-5 Y0001417 1,880.19CNY Detail

171596-29-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name Tildenafil

1.2 Other means of identification

Product number -
Other names Cialis

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:171596-29-5 SDS

Please post your buying leads,so that our qualified suppliers will soon contact you!

*Required Fields