531512-50-2Relevant academic research and scientific papers
A tandem Petasis-Ugi multi component condensation reaction: Solution phase synthesis of six dimensional libraries
Portlock, David E.,Ostaszewski, Ryszard,Naskar, Dinabandhu,West, Laura
, p. 603 - 605 (2003)
Amino acids with three points of diversity generated from the Petasis boronic acid-Mannich reaction can be used as one of the four components of the Ugi condensation to prepare six dimensional libraries of dipeptide amides.
Solid-phase synthesis of five-dimensional libraries via a tandem Petasis-Ugi multi-component condensation reaction
Portlock, David E.,Naskar, Dinabandhu,West, Laura,Ostaszewski, Ryszard,Chen, Jack J.
, p. 5121 - 5124 (2007/10/03)
Five-dimensional libraries of dipeptide amides are readily prepared using a solid-phase tandem Petasis-Ugi multi-component condensation protocol on either a RINK amine or Universal RINK isonitrile resin. The method is practical and can be automated to prepare a large number of compounds useful for high throughput biological screening.
