53166-66-8

Basic information

• Product Name: N-(2-methoxypyrimidin-4-yl)benzamide
• Synonyms: N-(2-methoxypyrimidin-4-yl)benzamide
• CAS NO: 53166-66-8
• Molecular Weight: 229.238
• Mol File: 53166-66-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(2-methoxypyrimidin-4-yl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-methoxypyrimidin-4-yl)benzamide(53166-66-8)
• EPA Substance Registry System: N-(2-methoxypyrimidin-4-yl)benzamide(53166-66-8)

Safety Data

• Hazardous Substances Data: 53166-66-8(Hazardous Substances Data)

Upstream product

• 3289-47-2 4-amino-2-methoxypyrimidine 
• 15226-74-1 dicobalt octacarbonyl 
• 591-50-4 iodobenzene 

Relevant articles and documents

Co2(CO)8as a Solid CO (g) Source for the Amino Carbonylation of (Hetero)aryl Halides with Highly Deactivated (Hetero)arylamines

Carbonylation of (hetero)aryl iodides/bromides with highly deactivated 2-aminopyridines using Pd-Co(CO)4 bimetallic catalysis is accomplished. The use of Co2(CO)8 as a solid CO(g) source enhanced reaction rates observed when compared to CO(g), and excellent yields highlight the versatility of the developed protocol. A wide range of electronically and sterically demanding heterocyclic amines and (hetero)aryl iodides/bromides employed for this study resulted in excellent yields of amino carbonylated products. The developed methodology was further extended to synthesize Trypanosome brucie and luciferase inhibitors.