3289-47-2Relevant articles and documents
Process for synthesis of cytosine
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Paragraph 0010; 0021, (2017/05/05)
The invention discloses a process for synthesizing cytosine. A 3-hydroxyacrylonitrile compound and an O-methylisourea compound or an S-methylisothiourea compound or an S-ethylisothiourea compound or an S-benzylisothiourea compound are used as raw materials. The process comprises the steps of adding a catalyst and an organic solvent into a reaction kettle, stirring, and then adding the raw materials; heating the mixture to be 50-90 DEG C, and reacting for 8-12 hours; evaporating the solvent to obtain an intermediate; adding concentrated hydrochloric acid into the intermediate, heating to be 70-100 DEG C, and preserving the heat for 1-2 hours; adding water, performing hot filtration, and cooling the obtained filtrate to room temperature; dripping a sodium hydroxide solution into the filtrate to adjust the pH value to be 7-7.5, and cooling to 10-15 DEG C; filtering after cooling, washing, and drying to obtain the cytosine. The process has the advantages that the process steps are simple, the production period is short, and the cost is low; the conversion rate of the raw materials is high, and the synthesized product is good in quality and high in yield, so that the process is suitable for industrialized production.
PEPTIDE DEFORMYLASE INHIBITORS
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Page/Page column, (2014/02/15)
The present invention relates to a compound of Formula (I): or a pharmaceutically acceptable salt thereof, corresponding pharmaceutical compositions, compound preparation and treatment methods directed to bacterial infections and inhi-bition of bacterial peptide deformylase (PDF) activity
PYRIMIDINE DERIVATIVES
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Page/Page column 65, (2008/12/04)
A compound of the following formula: wherein R1, R2, R3, R4, R5,T, U, V, X, Y, Z, G, and Z are defined herein. It also discloses a method of treating an angiogenesis-related disorder, e.g., cancer or age-related macular degeneration, with such a compound.