5317-87-3

Basic information

• Product Name: N-(3-acetylphenyl)-4-methylbenzenesulfonamide
• Synonyms: benzenesulfonamide, N-(3-acetylphenyl)-4-methyl-
• CAS NO: 5317-87-3
• Molecular Formula: C₁₅H₁₅NO₃S
• Molecular Weight: 289.3495
• Mol File: 5317-87-3.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 456.9°C at 760 mmHg
• Flash Point: 230.1°C
• Density: 1.278g/cm³
• Vapor Pressure: 1.55E-08mmHg at 25°C
• Refractive Index: 1.604
• CAS DataBase Reference: N-(3-acetylphenyl)-4-methylbenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-acetylphenyl)-4-methylbenzenesulfonamide(5317-87-3)
• EPA Substance Registry System: N-(3-acetylphenyl)-4-methylbenzenesulfonamide(5317-87-3)

Safety Data

• Hazardous Substances Data: 5317-87-3(Hazardous Substances Data)

Usage

General Description

N-(3-acetylphenyl)-4-methylbenzenesulfonamide is a sulfonamide compound with the chemical formula C15H15NO3S. It is primarily used as a pharmaceutical intermediate for the synthesis of potential drug candidates due to its ability to inhibit the growth of microorganisms. This chemical is also known for its anti-inflammatory and analgesic properties, making it a potential candidate for the treatment of various medical conditions. Its molecular structure consists of a benzene ring with a methyl group and a sulfonamide group attached, as well as an acetylphenyl group, making it a versatile compound with potential applications in medicine and pharmaceutical research.

Upstream product

• 99-03-6 1-(3-aminophenyl)ethanone 
• 98-59-9 p-toluenesulfonyl chloride 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 121-89-1 3-Nitroacetophenone 

Downstream Products

• 1477503-65-3 4-methyl-N-(3-(6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl)phenyl)benzenesulfonamide 

Relevant articles and documents

Straightforward and Sustainable Synthesis of Sulfonamides in Water under Mild Conditions

Ideally, a sustainable chemical synthesis should involve the use of non-toxic solvents and reactants, easy separations and purification by energy-efficient processes. In this context, reconsidering the synthesis of widely used drugs is especially timely and should allow important benefits to be obtained in terms of environmental impact. Sulfonamides are pertinent as their synthesis generally requires the use of toxic and/or hard-to-remove solvents such as dichloromethane, DMF and DMSO. In addition, toxic and highly reactive sulfur-containing sources such as sulfonyl chloride are often involved and coupled with amines. Moreover, the latter may exhibit some toxicity and are generally difficult to purify. Herein, we disclose the unprecedented and sustainable synthesis of sulfonamides by using sodium sulfinate as a commercial and stable sulfur source and nitroarenes as the nitrogen-containing reactant. In addition, under the optimized conditions only water is used as a “green” solvent and the products are collected by simple filtration.

Synthesis and biological evaluation of glucagon-like peptide-1 receptor agonists

In this study, a series of fused-heterocyclic derivatives were systematically designed and synthesized using an efficient route, and evaluated in terms of GLP-1R agonist activity. We employed short synthetic steps and reactions that are tolerant of the presence of various functional groups and suitable for parallel operations to enable the rapid generation of libraries of diverse and structurally complex small molecules. Of the compounds synthesized, 3-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a] pyridin-2-yl)phenyl methanesulfonate (8e) was the most potent agonist with an EC50 of 7.89 μM, and thus is the compound with the greatest potential for application. These findings represent a valuable starting point for the design and discovery of small-molecule GLP-1R agonists that can be administered orally.

Sulfonanilides. I. Monoalkyl- and arylsulfonamidophenethanolamines.

-