53176-99-1

Upstream product

• 119005-02-6 (S)-((3aR,3bS,5aS,6S,8aS,8bS,10R,10aR)-10-Methoxy-3a,5a-dimethyl-hexadecahydro-cyclopenta[a]cyclopropa[2,3]cyclopenta[1,2-f]naphthalen-6-yl)-phenylselanyl-acetic acid ethyl ester 
• 96354-27-7 lithium acetylide of 2-methyl-3-butyn-2-ol 
• 119005-07-1 (Z)-21-(((bromomethyl)dimethylsilyl)oxy)-6β-methoxy-3α,5α-cyclopregn-17(20)-ene 
• 64338-43-8 [(3aR,3bS,5aS,8aS,8bS,10R,10aR)-10-Methoxy-3a,5a-dimethyl-tetradecahydro-cyclopenta[a]cyclopropa[2,3]cyclopenta[1,2-f]naphthalen-(6E)-ylidene]-acetic acid ethyl ester 
• 87726-19-0 ethyl (Z)-6β-methoxy-3α,5α-cyclopregn-17(20)-en-21-oate 
• 119068-30-3 (Z)-6β-methoxy-3α,5α-cyclopregn-17(20)en-21-ol 
• 119005-08-2 Toluene-4-sulfonic acid (S)-2-((3aR,3bS,5aS,6R,8aS,8bS,10R,10aR)-10-methoxy-3a,5a-dimethyl-hexadecahydro-cyclopenta[a]cyclopropa[2,3]cyclopenta[1,2-f]naphthalen-6-yl)-6-methyl-6-(tetrahydro-pyran-2-yloxy)-hept-4-ynyl ester 
• 119005-05-9 (20S)-6β-methoxy-25-((2'-tetrahydropyranyl)oxy)-23,24-bisdehydro-3α,5α-cyclocholestan-21-ol 
• 74348-77-9 ethyl 6β-methoxy-3α,5α-cyclopregnan-21-oate 
• 126640-58-2 4-((3aR,3bS,5aS,6R,8aS,8bS,10R,10aR)-10-Methoxy-3a,5a-dimethyl-hexadecahydro-cyclopenta[a]cyclopropa[2,3]cyclopenta[1,2-f]naphthalen-6-yl)-2,2-dimethyl-[1,2]oxasilolane 
• 119005-03-7 6β-methoxy-3α,5α-cyclobisnorcholane-21,22-diol 
• 119005-04-8 6β-methoxy-21,22-epoxy-3α,5α-cyclobisnorcholane 
• 119068-31-4 (20S)-6β-methoxy-25-((2'-tetrahydropyranyl)oxy)-23,24-didehydro-3α,5α-cyclocholestane 
• 14425-92-4 (R)-10-Methoxy-3a,5a-dimethyl-tetradecahydro-cyclopenta[a]cyclopropa[2,3]cyclopenta[1,2-f]naphthalen-6-one 

Relevant academic research and scientific papers

METHYLATION AND HYDROXYMETHYLATION INVOLVING FREE RADICALS. AN APPLICATION TO STEREOSELECTIVE CONSTRUCTION OF 20(S) STEROL SIDE-CHAIN

Reductive radical cyclization of bromomethyl-silyl-ethers 1b and 2b was found to proceed in 5-exo-mode.Epimeric cyclic siloxanes 3 were transformed stereoselectively into 20(S) 25-hydroxycholesterol.Unsaturated (E) ester 4 was converted to its (Z) isomer 7 via saturation and selective dehydrogenation.

STEREOCONTROLLED SYNTHESIS OF STEROID SIDE CHAIN; STEREOSELECTIVE SYNTHESES OF CHOLESTEROL AND 25-HYDROXYCHOLESTEROL

Novel stereoselective method to introduce side chain onto 17-oxosteroids has been deviced, and using the method cholesterol and 25-hydroxycholesterol are synthesized.