5319-84-6Relevant academic research and scientific papers
Synthesis of 2′-(substituted)benzylidene hydrazino-5-arylamino-1,3,4- thiadiazoles and their antimicrobial activity
Burghate, Megha K.,Gandhe, Shital V.,Ajmire,Berad
, p. 103 - 108 (2008/03/11)
Several 2′-(substituted)benzylidene hydrazino-5-arylamino-1,3,4- thiadiazoles (5a-m) have been synthesized by the condensation of 1-(N-aryl thioamido)thiocarbohydrazides (3a-f) and different aromatic aldehydes in benzene medium, followed by intramolecular cyclization of compounds (4a-m) in refluxing ethanol medium. The former in turn have been prepared by the reaction of aryl isothiocynates (2a-f) and thiocarbohydrazide (1). Compounds (5a-m) on bromination with bromine in glacial acetic acid afforded dibromo derivatives (6a-m). The synthesized compounds were assayed for their antimicrobial activity against gram positive as well as gram negative micro-organisms.
