5322-56-5Relevant academic research and scientific papers
Increasing Complexity: A Practical Synthetic Approach to Three-Dimensional, Cyclic Sulfoximines and First Insights into Their in Vitro Properties
Boulard, Emilie,Ganzer, Ursula,Lücking, Ulrich,Lienau, Philip,Oertel, Luisa,Sch?fer, Martina,Zibulski, Vivien
, (2020/03/23)
A short synthetic approach with broad scope to access five- to seven-membered cyclic sulfoximines in only two to three steps from readily available thiophenols is reported. Thus, simple building blocks were converted to complex molecular structures by a s
Further evaluation of the tropane analogs of haloperidol
Sampson, Dinithia,Bricker, Barbara,Zhu, Xue Y.,Peprah, Kwakye,Lamango, Nazarius S.,Setola, Vincent,Roth, Bryan L.,Ablordeppey, Seth Y.
, p. 4294 - 4297 (2014/09/29)
Previous work from our labs has indicated that a tropane analog of haloperidol with potent D2 binding but designed to avoid the formation of MPP+-like metabolites, such as 4-(4-chlorophenyl)-1-(4- (4-fluorophenyl)-4-oxobutyl)pyridin-
Synthesis and QSAR studies on hypotensive 1-[3-(4-substituted phenylthio) propyl]-4-(substituted phenyl) piperazines
Saxena, Anil K.,Rao, Jyoti,Chakrabarty, Ruchika,Saxena, Mridula,Srimal
, p. 1708 - 1712 (2007/10/03)
A series of 1-[3-(4-substituted phenylthio) propyl]-4-(substituted phenyl) piperazines has been synthesized and evaluated for hypotensive activity. The QSAR studies indicate that resonance and hydrophobic parameters of the aryl substituents are important
5-HT7 receptor antagonists
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, (2008/06/13)
The present invention relates to compounds having pharmacological activity toward the 5-HT7receptor. Pharmaceutical compositions and methods for their use in the treatment of CNS disorders are described.
Substituted thiazolyl and substituted pyridinyl derivatives
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, (2008/06/13)
Substituted thiazolyl and substituted pyridinyl derivatives of formula STR1 the pharmaceutically acceptable acid addition salts and the stereochemically isomeric forms thereof, wherein --A1 =A2 --A3 =A4 -- is a
Central nervous system antiischemic agents
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, (2008/06/13)
A series of phenylalkylaminoalkyl derivatives of Formula I wherein Ar is naphtyl or phenyl; R1 is hydrogen, fluoro or R?CONH-; R2 is hydrogen or C?-? alkyl; R? is C?-? alkyl; R? is C?-? alkyl or phenyl-C?- ? alkyl; x is zero or the integers 1 and 2; m is
