53249-34-6

Basic information

• Product Name: N-Boc-4-Hydroxyphenyl-DL-glycine
• Synonyms: N-BOC-4-HYDROXYPHENYL-DL-GLYCINE;TERT-BUTOXYCARBONYLAMINO-(4-HYDROXY-PHENYL)-ACETIC ACID;2-(BOC-AMINO)-2-(4'-HYDROXYPHENYL)ACETIC ACID;BOC-D-4-Hydroxyphenylglycine;Benzeneacetic acid, .alpha.-[[(1,1-dimethylethoxy)carbonyl]amino]-4-hydroxy-;2-(tert-butoxycarbonylamino)-2-(4-hydroxyphenyl)acetic acid;Boc-2-amino-2-(4-hydroxyphenyl)acetic acid;Boc-D,L-Phg(4-OH)-OH
• CAS NO: 53249-34-6
• Molecular Formula: C₁₃H₁₇NO₅
• Molecular Weight: 267.28
• EINECS: 1533716-785-6
• Product Categories: pharmacetical
• Mol File: 53249-34-6.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 463.1 °C at 760 mmHg
• Flash Point: 233.9 °C
• Appearance: /
• Density: 1.267g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.582
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.71±0.10(Predicted)
• CAS DataBase Reference: N-Boc-4-Hydroxyphenyl-DL-glycine(CAS DataBase Reference)
• NIST Chemistry Reference: N-Boc-4-Hydroxyphenyl-DL-glycine(53249-34-6)
• EPA Substance Registry System: N-Boc-4-Hydroxyphenyl-DL-glycine(53249-34-6)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 53249-34-6(Hazardous Substances Data)

Usage

General Description

N-Boc-4-Hydroxyphenyl-DL-glycine is a chemical compound that consists of a tertiary butyloxycarbonyl (Boc) group attached to a 4-hydroxyphenyl group and a glycine molecule in a racemic mix. It is a white to off-white powder with a molecular formula C15H19NO5 and a molecular weight of 289.31 g/mol. N-Boc-4-Hydroxyphenyl-DL-glycine is used in the pharmaceutical industry as a building block for the synthesis of various drugs and pharmaceutical intermediates. As an amino acid derivative, N-Boc-4-Hydroxyphenyl-DL-glycine has potential applications in the development of peptide-based drugs and as a chiral auxiliary in asymmetric synthesis. Its unique structure and properties make it a valuable component in the production of pharmaceutical compounds.

InChI:InChI=1/C13H17NO5/c1-13(2,3)19-12(18)14(8-11(16)17)9-4-6-10(15)7-5-9/h4-7,15H,8H2,1-3H3,(H,16,17)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 6324-01-2 p-hydroxyphenylglycine 
• 56613-49-1 N-t-butoxycarbonyl-2-acetoxyglycine n-butyl ester 
• 1070-19-5 N-(tert-butyloxycarbonyl) azide 
• 122-87-2 N-(hydroxyphenyl)glycine 
• 7732-18-5 water 
• 497-19-8 sodium carbonate 
• 870-46-2 t-butoxycarbonylhydrazine 

Downstream Products

• 143323-49-3 (R)-methyl 2-((tert-butoxycarbonyl)amino)-2-(4-hydroxyphenyl)acetate 
• 1220904-99-3 C₃₂H₃₆N₂O₆ 
• 1220904-98-2 C₂₅H₃₀N₂O₆ 
• 1245201-59-5 [2-((S)-3-fluoropyrrolidin-1-yl)-1-(4-hydroxyphenyl)-2-oxoethyl]carbamic acid tert-butyl ester 
• 1245201-62-0 [2-((S)-2-carbamoylpyrrolidin-1-yl)-1-(4-hydroxyphenyl)-2-oxoethyl]carbamic acid tert-butyl ester 
• 918337-11-8 tert-butoxycarbonylamino-[4-(4-formylphenoxy)-phenyl]-acetic acid 
• 63856-23-5 N-tert-butoxycarbonyl-2-(4-hydroxyphenyl)-glycine phenacyl ester 
• 75986-12-8 (+/-)-epi-benzyl 3-acetylamino-O-benzylnocardicinate 
• 75986-12-8 (+/-)-benzyl 3-acetylamino-O-benzylnocardicinate 
• 79644-53-4 1-<(p-benzyloxyphenyl)benzyloxycarbonylmethyl>azetidine-2,3-dione 
• 75986-02-6 α-amino-4-(phenylmethoxy)benzeneacetic acid phenylmethyl ester HCl 
• 75986-06-0 benzyl α-(3-hydroxy-3-hydroxymethyl-2-oxo-1-azetidinyl)-p-benzyloxyphenylacetate 
• 79644-54-5 benzyl α-(3-hydroxyimino-2-oxo-1-azetidinyl)-p-benzyloxyphenylacetate 
• 75986-04-8 benzyl α-(2-oxo-3-methylene-1-azetidinyl)-p-benzyloxyphenylacetate 

Relevant articles and documents

Cefprozil refining method

The invention discloses a cefprozil refining method. The method includes: (1) dissolving a crude cefprozil product in a mixed solvent of deionized water, ethanol and dichloromethane, conducting heating reflux dissolution to prepare a saturated or supersaturated solution; (2) performing cooling to 20-30DEG C, adding activated carbon for decolorization, conducting filtration, cooling the filtrate to5DEG C-10DEG C, performing crystallization for 1h, conducting cooling to 0DEG C-5DEG C, and performing crystal growing; (3) conducting filtering, and performing leaching with ethanol to obtain a white solid; and (4) placing the white solid obtained by step (3) in a vacuum drying box, conducting vacuum pumping, and performing drying for 3h or more, thus obtaining cefprozil crystals. The refining method provided by the invention remarkably improves the product quality, and is simple in operation, thus being suitable for industrial production.

Method of preparing cephalosporins using 4-hydroxyphenylglycine derivatives

High purity cephalosporin compound can be easily prepared in a high yield by a process comprising the steps of: reacting a cephem compound with a 4-hydroxyphenylglycine derivative.

A NOVEL SYNTHESIS OF (+/-)-3-AMINONOCARDICINIC ACID

(+/-)-3-Aminonocardicinic acid (3-ANA, 2), which is an important material for the synthesis of nocardicin A (1) and other biologically active analogues, has been synthesized by the application of a new method for the synthesis of α-methylene-β-lactams.